Drug metabolism and disposition: the biological fate of chemicals

Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U

In vitro evaluation of the disposition of A novel cysteine protease inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Christians U, Benet LZ

Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism.

Drug metabolism and disposition: the biological fate of chemicals

Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ

Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism.

Drug metabolism and disposition: the biological fate of chemicals

Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ

Molecular and physical mechanisms of first-pass extraction.

Drug metabolism and disposition: the biological fate of chemicals

Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA

Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U

Molecular and physical mechanisms of first-pass extraction.

Drug metabolism and disposition: the biological fate of chemicals

Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA

Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U

Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide.

Drug metabolism and disposition: the biological fate of chemicals

Mohri K, Okada K, Benet LZ

Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Zhang Y, Guo X, Lin ET, Benet LZ

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