Drug metabolism and disposition: the biological fate of chemicals

CommentaryPharmacokinetic Theory Must Consider Published Experimental Data.

Benet LZ, Sodhi JK

Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide A Useful Improvement in In Vitro-In Vivo Extrapolation (IVIVE) Predictability?

Drug metabolism and disposition: the biological fate of chemicals

Kameyama T, Sodhi J, Benet LZ

Are there any experimental perfusion data that preferentially support the dispersion and parallel tube models over the well-stirred model of organ elimination?

Drug metabolism and disposition: the biological fate of chemicals

Sodhi JK, Wang HJ, Benet LZ

Protein binding and hepatic clearance: Re-examining the discrimination between models of hepatic clearance with diazepam in the isolated perfused rat liver preparation.

Drug metabolism and disposition: the biological fate of chemicals

Wang HJ, Benet LZ

In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Benet LZ

The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats.

Drug metabolism and disposition: the biological fate of chemicals

Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ

Characterization of fasiglifam-related liver toxicity in dogs.

Drug metabolism and disposition: the biological fate of chemicals

Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ

The Presence of a Transporter-Induced Protein Binding Shift: A new Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Okochi H, Benet LZ

Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Benet LZ

Hepatic clearance predictions from in vitro-in vivo extrapolation and BDDCS.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Benet LZ

Hair Analytical Lab

Drug metabolism and disposition: the biological fate of chemicals

CommentaryPharmacokinetic Theory Must Consider Published Experimental Data.

Does Addition of Protein to Hepatocyte or Microsomal In Vitro Incubations Provide A Useful Improvement in In Vitro-In Vivo Extrapolation (IVIVE) Predictability?

Are there any experimental perfusion data that preferentially support the dispersion and parallel tube models over the well-stirred model of organ elimination?

Protein binding and hepatic clearance: Re-examining the discrimination between models of hepatic clearance with diazepam in the isolated perfused rat liver preparation.

In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly.

The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats.

Characterization of fasiglifam-related liver toxicity in dogs.

The Presence of a Transporter-Induced Protein Binding Shift: A new Explanation for Protein-Facilitated Uptake and Improvement for In Vitro-In Vivo Extrapolation.

Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.

Hepatic clearance predictions from in vitro-in vivo extrapolation and BDDCS.

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Drug metabolism and disposition: the biological fate of chemicals

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