Leslie Benet, PhD

Professor
[email protected]

Dr. Benet is a Professor and former Chairman (1978-1998) of the Department of Bioengineering and Therapeutic Sciences at UCSF. He has published more than 550 peer-reviewed papers and book chapters and is listed among Thompson Reuter’s Most Highly Cited Pharmacologists worldwide, with his peer reviewed publications having been cited on more than 24,000 occasions. Dr. Benet is a pioneer in the pharmacokinetics/pharmacodynamics (PKPD) field and serves as the General Director of the UCSF HAL.

Publications: 

Is there a possibility that P-glycoprotein reduces reproductive toxicity in males but breast cancer resistance protein does not?

Clinical and translational science

Yu Z, Liu W, Wang Z, Chen Y, Yan J, Benet LZ, Zhai S

CommentaryPharmacokinetic Theory Must Consider Published Experimental Data.

Drug metabolism and disposition: the biological fate of chemicals

Benet LZ, Sodhi JK

The potential of developing high hepatic clearance drugs via controlled release: Lessons from Kirchhoff's Laws.

Journal of controlled release : official journal of the Controlled Release Society

Benet LZ, Tiitto MV, Sodhi JK

Are all measures of liver Kpuu a function of FH, as determined following oral dosing, or have we made a critical error in defining hepatic drug clearance?

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Benet LZ, Sodhi JK

Using an animal model to predict the effective human dose for oral multiple sclerosis drugs.

Clinical and translational science

Liu W, Yu Z, Wang Z, Waubant EL, Zhai S, Benet LZ

Batch Selection via In Vitro/In Vivo Correlation in Pharmacokinetic Bioequivalence Testing.

AAPS PharmSciTech

Burmeister Getz E, Carroll KJ, Mielke J, Jones B, Benet LZ

Tenofovir and Emtricitabine Concentrations in Hair are Comparable between Individuals on Tenofovir Disoproxil Fumarate versus Tenofovir Alafenamide-based ART.

Drug testing and analysis

Okochi H, Louie A, Phung N, Zhang K, Tallerico RM, Kuncze K, Spinelli MA, Koss CA, Benet LZ, Gandhi M

Volume of Distribution is Unaffected by Metabolic Drug-Drug Interactions.

Clinical pharmacokinetics

Sodhi JK, Huang CH, Benet LZ

The Critical Role of Passive Permeability in Designing Successful Drugs.

ChemMedChem

Di L, Artursson P, Avdeef A, Benet L, Houston B, Kansy M, Kerns E, Lennernäs H, Smith D, Sugano K

Can BDDCS illuminate targets in drug design?

Drug discovery today

Bocci G, Benet LZ, Oprea TI

In Vitro - In Vivo Accuracy: The CYP3A4 Anomaly.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Benet LZ

How Transporters Have Changed Basic Pharmacokinetic Understanding.

The AAPS journal

Benet LZ, Bowman CM, Sodhi JK

The enhancement of subcutaneous first-pass metabolism causes non-linear pharmacokinetics of TAK-448 after a single subcutaneous administration to rats.

Drug metabolism and disposition: the biological fate of chemicals

Moriya Y, Kogame A, Tagawa Y, Morohashi A, Kondo T, Asahi S, Benet LZ

Understanding drug-drug interaction and pharmacogenomic changes in pharmacokinetics for metabolized drugs.

Journal of pharmacokinetics and pharmacodynamics

Benet LZ, Bowman CM, Koleske ML, Rinaldi CL, Sodhi JK

In vitro-in vivo extrapolation and hepatic clearance dependent underprediction.

Journal of pharmaceutical sciences

Bowman CM, Benet LZ

Characterization of fasiglifam-related liver toxicity in dogs.

Drug metabolism and disposition: the biological fate of chemicals

Kogame A, Moriya Y, Mori I, Pan L, Morohashi A, Ebihara T, Fukui H, Tagawa Y, Benet LZ

Batch-to-Batch and Within-Subject Variability: What Do We Know and How Do These Variabilities Affect Clinical Pharmacology and Bioequivalence?

Clinical pharmacology and therapeutics

Benet LZ, Jayachandran P, Carroll KJ, Burmeister Getz E

Evaluating Within-Subject Variability for Narrow Therapeutic Index Drugs.

Clinical pharmacology and therapeutics

Jayachandran P, Okochi H, Frassetto LA, Park W, Fang L, Zhao L, Benet LZ

TPT sulfonate, a single, oral dose schistosomicidal prodrug: In vivo efficacy, disposition and metabolic profiling.

International journal for parasitology. Drugs and drug resistance

Wolfe AR, Neitz RJ, Burlingame M, Suzuki BM, Lim KC, Scheideler M, Nelson DL, Benet LZ, Caffrey CR

Ascorbic acid metabolites are involved in intraocular pressure control in the general population.

Redox biology

Hysi PG, Khawaja AP, Menni C, Tamraz B, Wareham N, Khaw KT, Foster PJ, Benet LZ, Spector TD, Hammond CJ

Development and Validation of an Immunoassay for Tenofovir in Urine as a Real-Time Metric of Antiretroviral Adherence.

EClinicalMedicine

Gandhi M, Bacchetti P, Rodrigues WC, Spinelli M, Koss CA, Drain PK, Baeten JM, Mugo NR, Ngure K, Benet LZ, Okochi H, Wang G, Vincent M

An examination of protein binding and protein-facilitated uptake relating to in vitro-in vivo extrapolation.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Bowman CM, Benet LZ

Measures of BSEP Inhibition In Vitro Are Not Useful Predictors of DILI.

Toxicological sciences : an official journal of the Society of Toxicology

Chan R, Benet LZ

A Drug-drug Interaction Between Cyclosporine and Nystatin.

Clinical therapeutics

Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S

Development and validation of an assay to analyze atazanavir in human hair via liquid chromatography/tandem mass spectrometry.

Rapid communications in mass spectrometry : RCM

Phung N, Kuncze K, Okochi H, Louie A, Benet LZ, Ofokotun I, Haas DW, Currier JS, Chawana TD, Sheth AN, Bacchetti P, Gandhi M, Horng H

Local delivery of hormonal therapy with silastic tubing for prevention and treatment of breast cancer.

Scientific reports

Park J, Thomas S, Zhong AY, Wolfe AR, Krings G, Terranova-Barberio M, Pawlowska N, Benet LZ, Munster PN

Comparison of Measures of Adherence to HIV Preexposure Prophylaxis among Adolescent and Young Men Who Have Sex with Men in the United States.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Koss CA, Hosek SG, Bacchetti P, Anderson PL, Liu AY, Horng H, Benet LZ, Kuncze K, Louie A, Saberi P, Wilson CM, Gandhi M

The Universally Unrecognized Assumption in Predicting Drug Clearance and Organ Extraction Ratio.

Clinical pharmacology and therapeutics

Benet LZ, Liu S, Wolfe AR

Commentary on: "Influence of OATP1B1 Function on the Disposition of Sorafenib-ß-D-Glucuronide".

Clinical and translational science

Morrissey KM, Benet LZ, Ware JA

Cellular Uptake of Levocetirizine by Organic Anion Transporter 4.

Journal of pharmaceutical sciences

Noguchi S, Nishimura T, Mukaida S, Benet LZ, Nakashima E, Tomi M

Rosuvastatin Pharmacokinetics in Asian and White Subjects Wild Type for Both OATP1B1 and BCRP Under Control and Inhibited Conditions.

Journal of pharmaceutical sciences

Wu HF, Hristeva N, Chang J, Liang X, Li R, Frassetto L, Benet LZ

Evaluation of DILI Predictive Hypotheses in Early Drug Development.

Chemical research in toxicology

Chan R, Benet LZ

Differences in Cumulative Exposure and Adherence to Tenofovir in the VOICE, iPrEx OLE, and PrEP Demo Studies as Determined via Hair Concentrations.

AIDS research and human retroviruses

Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M

Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.

Pharmaceutical research

Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ

Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study.

The lancet. HIV

Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM

Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Benet LZ

2016 Remington Honor Medal Address: Science for the profession.

Journal of the American Pharmacists Association : JAPhA

Benet LZ

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M

BDDCS, the Rule of 5 and drugability.

Advanced drug delivery reviews

Benet LZ, Hosey CM, Ursu O, Oprea TI

A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia.

Clinical lymphoma, myeloma & leukemia

Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG

The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.

The AAPS journal

Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA

Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients.

Transplantation

Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ

Mouse liver repopulation with hepatocytes generated from human fibroblasts.

Nature

Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.

Molecular pharmaceutics

Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA

Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.

Molecular pharmaceutics

Estudante M, Maya M, Morais JG, Soveral G, Benet LZ

Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.

Biopharmaceutics & drug disposition

Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L

Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.

Molecular pharmaceutics

Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ

Characterization of the acyl-adenylate linked metabolite of mefenamic Acid.

Chemical research in toxicology

Horng H, Benet LZ

Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.

Pharmaceutical research

Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB

Intestinal drug transporters: an overview.

Advanced drug delivery reviews

Estudante M, Morais JG, Soveral G, Benet LZ

Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?

Clinical pharmacology and therapeutics

Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA

Sotalol permeability in cultured-cell, rat intestine, and PAMPA system.

Pharmaceutical research

Liu W, Okochi H, Benet LZ, Zhai SD

BDDCS class prediction for new molecular entities.

Molecular pharmaceutics

Broccatelli F, Cruciani G, Benet LZ, Oprea TI

Improving the prediction of the brain disposition for orally administered drugs using BDDCS.

Advanced drug delivery reviews

Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ

Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations.

Pharmacotherapy

Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL

Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients.

Drug metabolism and disposition: the biological fate of chemicals

Grover A, Frassetto LA, Benet LZ, Chakkera HA

BDDCS applied to over 900 drugs.

The AAPS journal

Benet LZ, Broccatelli F, Oprea TI

Lead PK commentary: predicting human pharmacokinetics.

Journal of pharmaceutical sciences

Rowland M, Benet LZ

Professor Akira Tsuji: scientist, educator, and leader.

Journal of pharmaceutical sciences

Terasaki T, Sugiyama Y, Benet LZ

The BCS, BDDCS, and regulatory guidances.

Pharmaceutical research

Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX

Is Ciprofloxacin a Substrate of P-glycoprotein?

Archives of drug information

Park MS, Okochi H, Benet LZ

Founding figures of pharmacokinetics: tribute to Malcolm Rowland.

Journal of pharmacokinetics and pharmacodynamics

Aarons L, Benet LZ

Clearance (née Rowland) concepts: a downdate and an update.

Journal of pharmacokinetics and pharmacodynamics

Benet LZ

Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.

Neurotoxicology

Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ

Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.

Clinical pharmacology and therapeutics

Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ

Membrane transporters in drug development.

Nature reviews. Drug discovery

Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease.

Clinical pharmacology and therapeutics

Sun H, Frassetto LA, Huang Y, Benet LZ

Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals

Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ

Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.

Journal of pharmaceutical sciences

de Souza J, Benet LZ, Huang Y, Storpirtis S

Effects of drug transporters on volume of distribution.

The AAPS journal

Grover A, Benet LZ

Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women.

Journal of acquired immune deficiency syndromes (1999)

Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM

Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4.

Journal of infection in developing countries

Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J

Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.

Chemical research in toxicology

Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA

The use of BDDCS in classifying the permeability of marketed drugs.

Pharmaceutical research

Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX

Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats.

Drug metabolism and disposition: the biological fate of chemicals

Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ

HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG

Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ

Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.

Journal of mass spectrometry : JMS

Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U

Effects of uptake and efflux transporter inhibition on erythromycin breath test results.

Clinical pharmacology and therapeutics

Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ

Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.

Drug metabolism and disposition: the biological fate of chemicals

Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.

Clinical pharmacology and therapeutics

Lau YY, Huang Y, Frassetto L, Benet LZ

Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.

The Journal of pharmacology and experimental therapeutics

Lam JL, Shugarts SB, Okochi H, Benet LZ

In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.

Drug metabolism and disposition: the biological fate of chemicals

Lam JL, Okochi H, Huang Y, Benet LZ

Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.

Drug metabolism and disposition: the biological fate of chemicals

Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET

Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.

Rapid communications in mass spectrometry : RCM

Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

Antimicrobial agents and chemotherapy

Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH

In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats.

Chemical research in toxicology

Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ

Effects of renal failure on drug transport and metabolism.

Pharmacology & therapeutics

Sun H, Frassetto L, Benet LZ

Effects of short-term alendronate on bone mineral density in haemodialysis patients.

Nephrology (Carlton, Vic.)

Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L

Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.

Transplantation

Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ

Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.

Journal of clinical pharmacology

Putnam WS, Woo JM, Huang Y, Benet LZ

Basic pharmacological interactions and how they may impact on one another.

Journal of acquired immune deficiency syndromes (1999)

Benet L

Novel percutaneous adventitial drug delivery system for regional vascular treatment.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M

Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.

British journal of pharmacology

Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N

Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.

Drug metabolism and disposition: the biological fate of chemicals

Sun H, Huang Y, Frassetto L, Benet LZ

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

International journal of pharmaceutics

Benet LZ, Cummins CL, Wu CY

Pharmacogenomics and transplantation: where are we?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Frassetto LA, Benet LZ

Biochemical mechanisms of cyclosporine neurotoxicity.

Molecular interventions

Serkova NJ, Christians U, Benet LZ

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.

The Journal of pharmacology and experimental therapeutics

Lau YY, Wu CY, Okochi H, Benet LZ

Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.

Drug metabolism and disposition: the biological fate of chemicals

Wu CY, Benet LZ

CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.

The Journal of pharmacology and experimental therapeutics

Cummins CL, Jacobsen W, Christians U, Benet LZ

Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro.

Drug metabolism and disposition: the biological fate of chemicals

Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ

In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat.

The Journal of pharmacology and experimental therapeutics

Li C, Grillo MP, Benet LZ

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.

The Journal of pharmacology and experimental therapeutics

Cummins CL, Salphati L, Reid MJ, Benet LZ

In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester.

Toxicology and applied pharmacology

Li C, Grillo MP, Benet LZ

Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.

Drug metabolism and pharmacokinetics

Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC

Pharmacokinetics of cyclosporine pre- and post-liver transplantation.

Journal of clinical pharmacology

Hebert MF, Wacher VJ, Roberts JP, Benet LZ

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

Planta medica

Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ

Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.

The Journal of pharmacology and experimental therapeutics

Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N

Changes in plasma protein binding have little clinical relevance.

Clinical pharmacology and therapeutics

Benet LZ, Hoener BA

Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U

Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation.

Journal of clinical pharmacology

Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

The Journal of pharmacology and experimental therapeutics

Cummins CL, Jacobsen W, Benet LZ

Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Unger M, Jacobsen W, Holzgrabe U, Benet LZ

Mechanisms of clinically relevant drug interactions associated with tacrolimus.

Clinical pharmacokinetics

Christians U, Jacobsen W, Benet LZ, Lampen A

Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro.

Drug metabolism and disposition: the biological fate of chemicals

Grillo MP, Benet LZ

Red wine decreases cyclosporine bioavailability.

Clinical pharmacology and therapeutics

Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A

The drug efflux-metabolism alliance: biochemical aspects.

Advanced drug delivery reviews

Benet LZ, Cummins CL

Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats.

Drug metabolism and disposition: the biological fate of chemicals

Grillo MP, Chiellini G, Tonelli M, Benet LZ

Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.

British journal of pharmacology

Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U

Active secretion and enterocytic drug metabolism barriers to drug absorption.

Advanced drug delivery reviews

Wacher VJ, Salphati L, Benet LZ

Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.

Transplantation proceedings

Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U

Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L

The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.

Clinical pharmacology and therapeutics

Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U

Chiral bioequivalence: effect of absorption rate on racemic etodolac.

Clinical pharmacokinetics

Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ

In vitro evaluation of the disposition of A novel cysteine protease inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Christians U, Benet LZ

Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U

Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants.

Journal of chromatography. B, Biomedical sciences and applications

Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI

Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.

The Journal of pharmacology and experimental therapeutics

Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U

Recommendations for bioequivalence testing of cyclosporine generics revisited.

Therapeutic drug monitoring

Christians U, First MR, Benet LZ

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.

British journal of pharmacology

Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U

Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.

Transplantation

Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE

Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism.

Drug metabolism and disposition: the biological fate of chemicals

Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.

Journal of controlled release : official journal of the Controlled Release Society

Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ

Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.

The Journal of pharmacology and experimental therapeutics

Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U

Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin.

British journal of clinical pharmacology

Mizuma T, McDonagh AF, Lin ET, Benet LZ

Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.

The Journal of pharmacology and experimental therapeutics

Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U

Understanding bioequivalence testing.

Transplantation proceedings

Benet LZ

Grapefruit juice activates P-glycoprotein-mediated drug transport.

Pharmaceutical research

Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ

Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U

Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.

Xenobiotica; the fate of foreign compounds in biological systems

Salphati L, Benet LZ

Molecular and physical mechanisms of first-pass extraction.

Drug metabolism and disposition: the biological fate of chemicals

Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA

Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.

Journal of chromatography. B, Biomedical sciences and applications

Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U

Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women.

Journal of clinical pharmacology

Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.

Journal of pharmaceutical sciences

Wacher VJ, Silverman JA, Zhang Y, Benet LZ

Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.

The Journal of pharmacology and experimental therapeutics

Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U

Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Zhang Y, Guo X, Lin ET, Benet LZ

Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide.

Drug metabolism and disposition: the biological fate of chemicals

Mohri K, Okada K, Benet LZ

Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals

Qiu Y, Burlingame AL, Benet LZ

Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone.

Drug metabolism and disposition: the biological fate of chemicals

Jang GR, Benet LZ

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine.

Clinical pharmacology and therapeutics

Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole.

Clinical pharmacology and therapeutics

Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF

Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo.

The Journal of pharmacology and experimental therapeutics

Yuan R, Sumi M, Benet LZ

Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection.

Journal of chromatography. B, Biomedical sciences and applications

Wu ST, Benet LZ, Lin ET

Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization.

Journal of chromatography. B, Biomedical sciences and applications

Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET

Evaluation of orally administered highly variable drugs and drug formulations.

Pharmaceutical research

Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL

Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus.

Journal of clinical pharmacology

Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH

Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.

British journal of clinical pharmacology

Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ

Morality play.

Science (New York, N.Y.)

Benet LZ

Acute dose-dependent disposition studies of nicotinic acid in rats.

Drug metabolism and disposition: the biological fate of chemicals

Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ

The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics.

Clinical pharmacology and therapeutics

Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ

Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes.

Xenobiotica; the fate of foreign compounds in biological systems

Jaeger W, Benet LZ, Bornheim LM

The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers.

Clinical pharmacology and therapeutics

Chang T, Benet LZ, Hebert MF

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine.

Clinical pharmacology and therapeutics

Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ

Kidney function and age are both predictors of pharmacokinetics of metformin.

Journal of clinical pharmacology

Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG

Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation.

Journal of clinical pharmacology

d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ

Stereoselective disposition of naproxen glucuronide in the rat.

Drug metabolism and disposition: the biological fate of chemicals

Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ

Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin.

Drug metabolism and disposition: the biological fate of chemicals

Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ

Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.

Drug metabolism and disposition: the biological fate of chemicals

Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ

Gender effects in pharmacokinetics and pharmacodynamics.

Drugs

Harris RZ, Benet LZ, Schwartz JB

Stereoselective binding properties of naproxen glucuronide diastereomers to proteins.

Journal of pharmacokinetics and biopharmaceutics

Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ

Bioequivalence and narrow therapeutic index drugs.

Pharmacotherapy

Benet LZ, Goyan JE

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine.

Clinical pharmacology and therapeutics

Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ

Basic principles of pharmacokinetics.

Toxicologic pathology

Benet LZ, Zia-Amirhosseini P

Biliary excretion of furosemide glucuronide in rabbits.

Biological & pharmaceutical bulletin

Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ

Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals

Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ

Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution.

Biological & pharmaceutical bulletin

Sekikawa H, Yagi N, Lin ET, Benet LZ

Hypersensitivity to nonsteroidal anti-inflammatory drugs.

Nature medicine

Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ

HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes.

Pharmaceutical research

Perotti BY, Prueksaritanont T, Benet LZ

Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro.

Xenobiotica; the fate of foreign compounds in biological systems

Ojingwa JC, Spahn-Langguth H, Benet LZ

Menopause: pharmacodynamics and pharmacokinetics.

Experimental gerontology

Gustavson LE, Benet LZ

Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration.

Biopharmaceutics & drug disposition

Han C, Jung P, Sanders SW, Lin ET, Benet LZ

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.

Journal of clinical pharmacology

Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH

Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma.

Journal of pharmacokinetics and biopharmaceutics

Ojingwa JC, Spahn-Langguth H, Benet LZ

Bioactivation by glucuronide-conjugate formation.

Advances in pharmacology (San Diego, Calif.)

Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ

Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing.

Clinical pharmacology and therapeutics

Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ

FK 506 metabolism in male and female rat liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals

Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ

Pharmacokinetic profile of etodolac in special populations.

European journal of rheumatology and inflammation

Benet LZ

Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients.

Journal of clinical pharmacology

Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ

Pharmacokinetics--a relevant factor for the choice of a drug?

Alimentary pharmacology & therapeutics

Benet LZ, Zech K

Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A.

Drug metabolism and disposition: the biological fate of chemicals

Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ

Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America

Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ

In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers.

Chirality

Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H

Pharmacokinetics of sustained-release etodolac.

Rheumatology international

Benet LZ

Predictability of the covalent binding of acidic drugs in man.

Life sciences

Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET

Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins.

Clinical pharmacology and therapeutics

Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction.

Clinical pharmacology and therapeutics

Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ

Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.

Anesthesiology

Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J

Effects of low-density lipoprotein and ethinyl estradiol on cyclosporine metabolism in isolated rat liver perfusions.

Drug metabolism and disposition: the biological fate of chemicals

Prueksaritanont T, Hoener BA, Benet LZ

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.

Journal of pharmaceutical sciences

Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.

Pharmaceutical research

Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH

Transport and metabolism of cyclosporine in isolated rat hepatocytes. The effects of lipids.

Biochemical pharmacology

Prueksaritanont T, Koike M, Hoener BA, Benet LZ

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.

Clinical pharmacology and therapeutics

Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH

Cutaneous metabolism of nitroglycerin in vitro. I. Homogenized versus intact skin.

Pharmaceutical research

Higo N, Hinz RS, Lau DT, Benet LZ, Guy RH

Stereoselective degradation of the fenoprofen acyl glucuronide enantiomers and irreversible binding to plasma protein.

Drug metabolism and disposition: the biological fate of chemicals

Volland C, Sun H, Dammeyer J, Benet LZ

Disposition of prednisone and prednisolone in the perfused rabbit liver: modeling hepatic metabolic processes.

Journal of pharmacokinetics and biopharmaceutics

Hale VG, Aizawa K, Sheiner LB, Benet LZ

Stereoselective disposition of carprofen, flunoxaprofen, and naproxen in rats.

Drug metabolism and disposition: the biological fate of chemicals

Iwakawa S, Spahn H, Benet LZ, Lin ET

Prednisone and prednisolone interconversion in the rabbit utilizing unbound concentrations.

Biopharmaceutics & drug disposition

Hammarlund-Udenaes M, Benet LZ

Nitroglycerin absorption from transdermal systems: formulation effects and metabolite concentrations.

Pharmaceutical research

Williams RL, Thakker KM, John V, Lin ET, Liang-Gee W, Benet LZ

Stereoselective disposition of ketoprofen in rats.

Drug metabolism and disposition: the biological fate of chemicals

Iwakawa S, He XW, Hashimoto S, Volland C, Benet LZ, Lin ET

Pharmacokinetic studies of the nitroglycerin metabolites, 1,2- and 1,3- glyceryl dinitrates, in the rat.

Biopharmaceutics & drug disposition

Lau DT, Gumbleton M, Labisch C, Benet LZ

Prednisolone and prednisone exhibit linear extraction in the perfused rabbit liver.

Drug metabolism and disposition: the biological fate of chemicals

Hale VG, Benet LZ

Safety and pharmacokinetics: colloidal bismuth subcitrate.

Scandinavian journal of gastroenterology. Supplement

Benet LZ

Stereoselective analysis of fenoprofen and its metabolites.

Journal of chromatography

Volland C, Sun H, Benet LZ

Pharmacokinetics and pharmacodynamics of glyceryl trinitrate and its two dinitrate metabolites in conscious dogs.

The Journal of pharmacology and experimental therapeutics

Lee FW, Salmonson T, Metzler CH, Benet LZ

Covalent binding of zomepirac glucuronide to proteins: evidence for a Schiff base mechanism.

Drug metabolism and disposition: the biological fate of chemicals

Smith PC, Benet LZ, McDonagh AF

Report of the workshop on in vitro and in vivo testing and correlation for oral controlled/modified-release dosage forms.

Journal of pharmaceutical sciences

Skelley JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A

Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up.

Transplantation proceedings

Manfro RC, Pohanka E, Tomlanovich SJ, Benet LZ, Salvatierra O, Garovoy MR

Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration.

Journal of clinical pharmacology

Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ

Pharmacokinetics of nitroglycerin and its dinitrate metabolites over a thirtyfold range of oral doses.

Clinical pharmacology and therapeutics

Nakashima E, Rigod JF, Lin ET, Benet LZ

Absorption and disposition of a new low-dose combination formulation of hydrochlorothiazide and triamterene.

Biopharmaceutics & drug disposition

Williams RL, Lin ET, Liang-Gee W, Blume CD, Benet LZ

Fetal uptake of intraamniotic digoxin in sheep.

Pediatric research

Hamamoto K, Iwamoto HS, Roman CM, Benet LZ, Rudolph AM

Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.

The Journal of pharmacology and experimental therapeutics

Smith PC, McDonagh AF, Benet LZ

High-fat meals increase the clearance of cyclosporine.

Pharmaceutical research

Gupta SK, Benet LZ

Irreversible binding of tolmetin glucuronic acid esters to albumin in vitro.

Pharmaceutical research

Munafo A, McDonagh AF, Smith PC, Benet LZ

The effect of acetaminophen on zidovudine metabolism in HIV-infected patients.

Journal of acquired immune deficiency syndromes

Steffe EM, King JH, Inciardi JF, Flynn NF, Goldstein E, Tonjes TS, Benet LZ

Pharmacokinetics of nicotinic acid-salicylic acid interaction.

Clinical pharmacology and therapeutics

Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ

Absorption kinetics of cyclosporine in healthy volunteers.

Biopharmaceutics & drug disposition

Gupta SK, Benet LZ

Application of clearance concepts to the assessment of exposure to lead in drinking water.

American journal of public health

Bois FY, Tozer TN, Zeise L, Benet LZ

Lead exposure in children vs adults.

American journal of public health

Bois FY, Tozer TN, Benet LZ, Zeise L

Prediction of the distribution volumes of cefazolin and tobramycin in obese children based on physiological pharmacokinetic concepts.

Pharmaceutical research

Koshida R, Nakashima E, Taniguchi N, Tsuji A, Benet LZ, Ichimura F

Probenecid-induced changes in the clearance of carprofen enantiomers: a preliminary study.

Clinical pharmacology and therapeutics

Spahn H, Spahn I, Benet LZ

Cyclosporin A and prednisolone: an additive inhibitory effect of cell proliferation and interleukin-2 production.

Transplantation proceedings

Manfro RC, Pohanka E, Tomlanovich S, Benet LZ, Garovoy MR

Furosemide pharmacokinetics and pharmacodynamics in health and disease--an update.

Journal of pharmacokinetics and biopharmaceutics

Hammarlund-Udenaes M, Benet LZ

Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing.

Biopharmaceutics & drug disposition

Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH

Disposition and irreversible plasma protein binding of tolmetin in humans.

Clinical pharmacology and therapeutics

Hyneck ML, Smith PC, Munafo A, McDonagh AF, Benet LZ

Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics.

Clinical pharmacology and therapeutics

Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ

Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide.

Drug metabolism and disposition: the biological fate of chemicals

Hyneck ML, Munafo A, Benet LZ

Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products.

Pharmaceutical research

Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ

Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin.

Journal of pharmacokinetics and biopharmaceutics

Nakashima E, Noonan PK, Benet LZ

Pharmacokinetics and excretion of unique beta-adrenergic agonists.

Pharmacology

Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N

AAPS and pharmaceutical research.

Pharmaceutical research

Benet LZ

Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function.

Clinical pharmacology and therapeutics

Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ

Characterization of the isomeric esters of zomepirac glucuronide by proton NMR.

Drug metabolism and disposition: the biological fate of chemicals

Smith PC, Benet LZ

Ethambutol kinetics in patients with impaired renal function.

The American review of respiratory disease

Varughese A, Brater DC, Benet LZ, Lee CS

Pharmacokinetic studies of the disposition of acetaminophen in the sheep maternal-placental-fetal unit.

The Journal of pharmacology and experimental therapeutics

Wang LH, Rudolph AM, Benet LZ

Irreversible binding of zomepirac to plasma protein in vitro and in vivo.

The Journal of clinical investigation

Smith PC, McDonagh AF, Benet LZ

The bioavailability of oral nitroglycerin.

Journal of pharmaceutical sciences

Noonan PK, Benet LZ

Metabolic fate and solubility of triamterene--not an explanation for triamterene nephrolithiasis.

Journal of pharmaceutical sciences

Sörgel F, Ettinger B, Benet LZ

Impairment of prednisolone disposition in women taking oral contraceptives or conjugated estrogens.

The Journal of clinical endocrinology and metabolism

Gustavson LE, Legler UF, Benet LZ

Distribution and fate of acetaminophen conjugates in fetal lambs in utero.

The Journal of pharmacology and experimental therapeutics

Wang LH, Rudolph AM, Benet LZ

Premarketing observational studies of population pharmacokinetics of new drugs.

Clinical pharmacology and therapeutics

Sheiner LB, Benet LZ

Mean residence time in the body versus mean residence time in the central compartment.

Journal of pharmacokinetics and biopharmaceutics

Benet LZ

Effect of probenecid on the formation and elimination of acyl glucuronides: studies with zomepirac.

Clinical pharmacology and therapeutics

Smith PC, Langendijk PN, Bosso JA, Benet LZ

Peptides and proteins as drugs.

Pharmaceutical research

Ferraiolo BL, Benet LZ

Dose dependent pharmacokinetics of nitroglycerin after multiple intravenous infusions in healthy volunteers.

Journal of pharmacokinetics and biopharmaceutics

Noonan PK, Williams RL, Benet LZ

Pharmacokinetics and metabolism of bepridil.

The American journal of cardiology

Benet LZ

Incomplete and delayed bioavailability of sublingual nitroglycerin.

The American journal of cardiology

Noonan PK, Benet LZ

Stability of acyl glucuronides in blood, plasma, and urine: studies with zomepirac.

Drug metabolism and disposition: the biological fate of chemicals

Smith PC, Hasegawa J, Langendijk PN, Benet LZ

Absence of a significant pharmacokinetic interaction between hydrochlorothiazide and triamterene when coadministered.

Journal of pharmacokinetics and biopharmaceutics

Upton RA, Williams RL, Lin ET, Gee WL, Blume CD, Benet LZ

Bioequivalence study of a new tablet formulation of triamterene and hydrochlorothiazide.

The American journal of medicine

Blume CD, Williams RL, Upton RA, Lin ET, Benet LZ

Pharmacokinetic parameters: which are necessary to define a drug substance?

European journal of respiratory diseases. Supplement

Benet LZ

Dose-dependent bioavailability of prazosin in beagle dogs.

Journal of cardiovascular pharmacology

Baughman RA, Sorgel F, Mico BA, Benet LZ

Oral bioavailability and intravenous pharmacokinetics of amrinone in humans.

Journal of pharmaceutical sciences

Park GB, Kershner RP, Angellotti J, Williams RL, Benet LZ, Edelson J

Furosemide assays and disposition in healthy volunteers and renal transplant patients.

Federation proceedings

Benet LZ, Smith DE, Lin ET, Vincenti F, Gambertoglio JG

The bioavailability and disposition of tiodazosin levulinate in beagle dogs with a comparison to prazosin hydrochloride.

Drug metabolism and disposition: the biological fate of chemicals

Baughman RA, Mico BA, Benet LZ

Biotransformation of furosemide in kidney transplant patients.

European journal of clinical pharmacology

Smith DE, Benet LZ

Plasma protein binding of furosemide in kidney transplant patients.

Journal of pharmacokinetics and biopharmaceutics

Smith DE, Benet LZ

Endogenous and exogenous glucocorticoids in cushingoid patients.

Drug intelligence & clinical pharmacy

Benet LZ, Frey FJ, Amend WJ, Lozada F, Frey BM

Disposition of zomepirac sodium in man.

Journal of clinical pharmacology

O'Neill PJ, Yorgey KA, Renzi NL, Williams RL, Benet LZ

Pharmacokinetics of triamterene and its metabolite in man.

Journal of pharmacokinetics and biopharmaceutics

Hasegawa J, Lin ET, Williams RL, Sörgel F, Benet LZ

Prednisolone clearance at steady state in man.

The Journal of clinical endocrinology and metabolism

Legler UF, Frey FJ, Benet LZ

Apparent intramolecular acyl migration of zomepirac glucuronide.

Drug metabolism and disposition: the biological fate of chemicals

Hasegawa J, Smith PC, Benet LZ

Specific and sensitive assay of celiprolol in blood, plasma and urine using high-performance liquid chromatography.

Journal of chromatography

Buskin JN, Upton RA, Sörgel F, Williams RL, Lang E, Benet LZ

Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction.

Transplantation

Frey BM, Frey FJ, Holford NH, Lozada F, Benet LZ

Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol.

Journal of pharmaceutical sciences

Williams RL, Blume CD, Lin ET, Holford NH, Benet LZ

Hydrochlorothiazide pharmacokinetics and pharmacologic effect: the influence of indomethacin.

Journal of clinical pharmacology

Williams RL, Davies RO, Berman RS, Holmes GI, Huber P, Gee WL, Lin ET, Benet LZ

Nonlinear plasma protein binding and haemodialysis clearance of prednisolone.

European journal of clinical pharmacology

Frey FJ, Gambertoglio JG, Frey BM, Benet LZ, Amend WJ

Effects of indomethacin and carprofen on renal homeostasis in rheumatoid arthritis patients and in healthy individuals.

Journal of clinical pharmacology

Williams RL, Furst DE, Mandel HG, Nicoll D, Konikoff JJ, Benet LZ

Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone.

The Journal of clinical endocrinology and metabolism

Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ

Saturable kinetics of intravenous chlorothiazide in the rhesus monkey.

Journal of pharmacokinetics and biopharmaceutics

Gustafson JH, Benet LZ

Furosemide kinetics and dynamics after kidney transplant.

Clinical pharmacology and therapeutics

Smith DE, Gambertoglio JG, Vincenti F, Benet LZ

A standard approach to compiling clinical pharmacokinetic data.

Journal of pharmacokinetics and biopharmaceutics

Sheiner LB, Benet LZ, Pagliaro LA

Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients.

European journal of clinical pharmacology

Frey FJ, Amend WJ, Lozada F, Frey BM, Holford NH, Benet LZ

Prednisolone clearance at steady state in dogs.

The Journal of pharmacology and experimental therapeutics

Frey FJ, Frey BM, Greither A, Benet LZ

Renal excretion of pseudoephedrine.

Clinical pharmacology and therapeutics

Brater DC, Kaojarern S, Benet LZ, Lin ET, Lockwood T, Morris RC, McSherry EJ, Melmon KL

Absorption and disposition of furosemide in healthy volunteers, measured with a metabolite-specific assay.

Drug metabolism and disposition: the biological fate of chemicals

Smith DE, Lin ET, Benet LZ

Disposition kinetics of ethambutol in man.

Journal of pharmacokinetics and biopharmaceutics

Lee CS, Brater DC, Gambertoglio JG, Benet LZ

Altered prazosin pharmacokinetics in congestive heart failure.

European journal of clinical pharmacology

Baughman RA, Arnold S, Benet LZ, Lin ET, Chatterjee K, Williams RL

Preliminary evaluation of furosemide-probenecid interaction in humans.

Journal of pharmaceutical sciences

Smith DE, Gee WL, Brater DC, Lin ET, Benet LZ

Clearance calculations in hemodialysis: application to blood, plasma, and dialysate measurements for ethambutol.

Journal of pharmacokinetics and biopharmaceutics

Lee CS, Marbury TC, Benet LZ

Inhibition by indomethacin of the glycemic response to arginine in man.

Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)

Schmitt JK, Davis JL, Lorenzi M, Benet LZ, Burns A, Karam JH

Pharmacokinetics and bioavailability of prednisone and prednisolone in healthy volunteers and patients: a review.

Journal of pharmacokinetics and biopharmaceutics

Gambertoglio JG, Amend WJ, Benet LZ

Drug pharmacokinetics in cardiac and hepatic disease.

Annual review of pharmacology and toxicology

Williams RL, Benet LZ

Renal excretion of pseudoephedrine in the rat.

The Journal of pharmacology and experimental therapeutics

Till AE, Benet LZ

Cefamandole kinetics in uremic patients undergoing hemodialysis.

Clinical pharmacology and therapeutics

Gambertoglio JG, Aziz NS, Lin ET, Grausz H, Naughton JL, Benet LZ

Comparative bioavailability and pharmacokinetic studies of azathioprine and 6-mercaptopurine in the rhesus monkey.

Drug metabolism and disposition: the biological fate of chemicals

Ding TL, Benet LZ

Attenuation of prazosin effect on cardiac output in chronic heart failure.

Annals of internal medicine

Arnold SB, Williams RL, Ports TA, Baughman RA, Benet LZ, Parmley WW, Chatterjee K

Noncompartmental determination of the steady-state volume of distribution.

Journal of pharmaceutical sciences

Benet LZ, Galeazzi RL

High-performance liquid chromatographic assays for furosemide in plasma and urine.

Journal of chromatography

Lin ET, Smith DE, Benet LZ, Hoener BA

Attenuation of furosemide's diuretic effect by indomethacin: pharmacokinetic evaluation.

Journal of pharmacokinetics and biopharmaceutics

Smith DE, Brater DC, Lin ET, Benet LZ

Pharmacokinetics/pharmacodynamics of furosemide in man: a review.

Journal of pharmacokinetics and biopharmaceutics

Benet LZ

Pharmacokinetics of furosemide in patients with congestive heart failure.

Pharmacology

Greither A, Goldman S, Edelen JS, Benet LZ, Cohn K

Effect of route of administration and distribution on drug action.

Journal of pharmacokinetics and biopharmaceutics

Benet LZ

Pharmacokinetics and pharmacodynamics of d-tubocurarine during hypothermia in the cat.

Anesthesiology

Ham J, Miller RD, Benet LZ, Matteo RS, Roderick LL

Micro and macro GLC determination of ethambutol in biological fluids.

Journal of pharmaceutical sciences

Lee CS, Benet LZ

Pharmacokinetics of cefamandole using a HPLC assay.

Journal of pharmacokinetics and biopharmaceutics

Aziz NS, Gambertoglio JG, Lin ET, Grausz H, Benet LZ

Acute massive chloral hydrate intoxication treated with hemodialysis: a clinical pharmacokinetic analysis.

Journal of clinical pharmacology

Stalker NE, Gambertoglio JG, Fukumitsu CJ, Naughton JL, Benet LZ

Ascorbate stimulation of salicylate absorption in isolated rat intestine.

Journal of pharmaceutical sciences

Barnett G, Lockwood T, Arancibia A, Benet LZ

Oral controlled release preparations.

Pharmaceutica acta Helvetiae

García CR, Siqueiros A, Benet LZ

Kinetics of oral ethambutol in the normal subject.

Clinical pharmacology and therapeutics

Lee CS, Gambertoglio JG, Brater DC, Benet LZ

The pharmacokinetics of d-tubocurarine in man with and without renal failure.

The Journal of pharmacology and experimental therapeutics

Miller RD, Matteo RS, Benet LZ, Sohn YJ

Interpretation of plasma concentration-time curves after oral dosing.

Journal of pharmaceutical sciences

Ronfeld RA, Benet LZ

Relationship between the pharmacokinetics and pharmacodynamics of procainamide.

Clinical pharmacology and therapeutics

Galeazzi RL, Benet LZ, Sheiner LB

Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities.

Journal of pharmaceutical sciences

Gustafson JH, Schoenwald RD, Benet LZ

The renal elimination of procainamide.

Clinical pharmacology and therapeutics

Galeazzi RL, Sheiner LB, Lockwood T, Benet LZ

An integrated approach to the pharmacokinetic analysis of drug absorption.

Journal of pharmacokinetics and biopharmaceutics

Till AE, Benet LZ, Kwan KC

Clearance concepts in pharmacokinetics.

Journal of pharmacokinetics and biopharmaceutics

Rowland M, Benet LZ, Graham GG

Gastrointestinal absorption of iopanoic acid.

Investigative radiology

Nelson JA, Moss AA, Goldberg HI, Benet LZ, Amberg J

Drug transfer across rat intestinal musculature after edetic acid treatment.

Journal of pharmaceutical sciences

Nayak RK, Benet LZ

Effect of buffer constituents and time on drug transfer across in vitro rat intestine.

Journal of pharmaceutical sciences

Benet LZ, Orr JM, Turner RH, Webb HS

Volume terms in pharmacokinetics.

Journal of pharmaceutical sciences

Benet LZ, Ronfeld RA

Potentiometric determination of dissociation constants.

Journal of pharmaceutical sciences

Benet LZ, Goyan JE

Thermodynamics of chelation by tetracyclines.

Journal of pharmaceutical sciences

Benet LZ, Goyan JE

Determination of the stability constants of tetracycline complexes.

Journal of pharmaceutical sciences

Benet LZ, Goyan JE