Leslie Benet, PhD | Hair Analytical Lab

Koss CA, Bacchetti P, Hillier SL, Livant E, Horng H, Mgodi N, Mirembe BG, Gomez Feliciano K, Horn S, Liu AY, Glidden DV, Grant RM, Benet LZ, Louie A, van der Straten A, Chirenje ZM, Marrazzo JM, Gandhi M

Meal Effects Confound Attempts to Counteract Rabeprazole-Induced Hypochlorhydria Decreases in Atazanavir Absorption.

Pharmaceutical research

Faber KP, Wu HF, Yago MR, Xu X, Kadiyala P, Frassetto LA, Benet LZ

Classification of natural products as sources of drugs according to the biopharmaceutics drug disposition classification system (BDDCS).

Chinese journal of natural medicines

Li J, Larregieu CA, Benet LZ

Between-Batch Pharmacokinetic Variability Inflates Type I Error Rate in Conventional Bioequivalence Trials: A Randomized Advair Diskus Clinical Trial.

Clinical pharmacology and therapeutics

Burmeister Getz E, Carroll KJ, Mielke J, Benet LZ, Jones B

Association of age, baseline kidney function, and medication exposure with declines in creatinine clearance on pre-exposure prophylaxis: an observational cohort study.

The lancet. HIV

Gandhi M, Glidden DV, Mayer K, Schechter M, Buchbinder S, Grinsztejn B, Hosek S, Casapia M, Guanira J, Bekker LG, Louie A, Horng H, Benet LZ, Liu A, Grant RM

Hepatic Clearance Predictions from In Vitro-In Vivo Extrapolation and the Biopharmaceutics Drug Disposition Classification System.

Drug metabolism and disposition: the biological fate of chemicals

Bowman CM, Benet LZ

2016 Remington Honor Medal Address: Science for the profession.

Journal of the American Pharmacists Association : JAPhA

Benet LZ

Isoniazid hair concentrations in children with tuberculosis: a proof of concept study.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease

Mave V, Chandanwale A, Kinikar A, Khadse S, Kagal A, Gupte N, Suryavanshi N, Nimkar S, Koli H, Khwaja S, Bharadwaj R, Joshi S, Horng H, Benet LZ, Ramachandran G, Dooley KE, Gupta A, Gandhi M

BDDCS, the Rule of 5 and drugability.

Advanced drug delivery reviews

Benet LZ, Hosey CM, Ursu O, Oprea TI

Batch-to-batch pharmacokinetic variability confounds current bioequivalence regulations: A dry powder inhaler randomized clinical trial.

Clinical pharmacology and therapeutics

Burmeister Getz E, Carroll KJ, Jones B, Benet LZ

Use of the Biopharmaceutics Drug Disposition Classification System (BDDCS) to Help Predict the Occurrence of Idiosyncratic Cutaneous Adverse Drug Reactions Associated with Antiepileptic Drug Usage.

The AAPS journal

Chan R, Wei CY, Chen YT, Benet LZ

Reliability of In Vitro and In Vivo Methods for Predicting the Effect of P-Glycoprotein on the Delivery of Antidepressants to the Brain.

Clinical pharmacokinetics

Zheng Y, Chen X, Benet LZ

BDDCS Predictions, Self-Correcting Aspects of BDDCS Assignments, BDDCS Assignment Corrections, and Classification for more than 175 Additional Drugs.

The AAPS journal

Hosey CM, Chan R, Benet LZ

Few Drugs Display Flip-Flop Pharmacokinetics and These Are Primarily Associated with Classes 3 and 4 of the BDDCS.

Journal of pharmaceutical sciences

Garrison KL, Sahin S, Benet LZ

Predicting the extent of metabolism using in vitro permeability rate measurements and in silico permeability rate predictions.

Molecular pharmaceutics

Hosey CM, Benet LZ

pH Dependent but not P-gp Dependent Bidirectional Transport Study of S-propranolol: The Importance of Passive Diffusion.

Pharmaceutical research

Zheng Y, Benet LZ, Okochi H, Chen X

A phase I study of targeted, dose-escalated intravenous busulfan in combination with etoposide as myeloablative therapy for autologous stem cell transplantation in acute myeloid leukemia.

Clinical lymphoma, myeloma & leukemia

Mannis GN, Andreadis C, Logan AC, Damon LE, Benet LZ, Ai WZ, Gaensler KM, Kaplan LD, Koplowicz YB, Linker CA, Olin RL, Sayre PH, Smith CC, Sudhindra A, Venstrom JM, Wolf JL, Martin TG

Inclusion of placebos and blinding for ascending dose first-in-human studies and other underpowered phase 1 studies has not been justified and on balance is not useful.

Basic & clinical pharmacology & toxicology

Parasrampuria DA, Benet LZ

The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.

The AAPS journal

Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA

Predicting when biliary excretion of parent drug is a major route of elimination in humans.

The AAPS journal

Hosey CM, Broccatelli F, Benet LZ

Distinguishing between the permeability relationships with absorption and metabolism to improve BCS and BDDCS predictions in early drug discovery.

Molecular pharmaceutics

Larregieu CA, Benet LZ

Best single time point correlations with AUC for cyclosporine and tacrolimus in HIV-infected kidney and liver transplant recipients.

Transplantation

Frassetto LA, Tan-Tam CC, Barin B, Browne M, Wolfe AR, Stock PG, Roland M, Benet LZ

Mouse liver repopulation with hepatocytes generated from human fibroblasts.

Nature

Zhu S, Rezvani M, Harbell J, Mattis AN, Wolfe AR, Benet LZ, Willenbring H, Ding S

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.

Molecular pharmaceutics

Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA

Effect of P-glycoprotein on the rat intestinal permeability and metabolism of the BDDCS class 1 drug verapamil.

Molecular pharmaceutics

Estudante M, Maya M, Morais JG, Soveral G, Benet LZ

Changes in clearance, volume and bioavailability of immunosuppressants when given with HAART in HIV-1 infected liver and kidney transplant recipients.

Biopharmaceutics & drug disposition

Frassetto L, Floren L, Barin B, Browne M, Wolfe A, Roland M, Stock P, Carlson L, Christians U, Benet L

Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.

Molecular pharmaceutics

Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ

The nonenzymatic reactivity of the acyl-linked metabolites of mefenamic acid toward amino and thiol functional group bionucleophiles.

Drug metabolism and disposition: the biological fate of chemicals

Horng H, Benet LZ

Characterization of the acyl-adenylate linked metabolite of mefenamic Acid.

Chemical research in toxicology

Horng H, Benet LZ

Pharmacokinetics and metabolism of 2-aminothiazoles with antiprion activity in mice.

Pharmaceutical research

Silber BM, Rao S, Fife KL, Gallardo-Godoy A, Renslo AR, Dalvie DK, Giles K, Freyman Y, Elepano M, Gever JR, Li Z, Jacobson MP, Huang Y, Benet LZ, Prusiner SB

Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurements.

The AAPS journal

Larregieu CA, Benet LZ

The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development.

Journal of pharmaceutical sciences

Benet LZ

A step closer to personalized chemotherapy: consideration of the influence of genetic variation in hepatic uptake transporters on the metabolism of CYP3A substrates.

Clinical pharmacology and therapeutics

Benet LZ

Intestinal drug transporters: an overview.

Advanced drug delivery reviews

Estudante M, Morais JG, Soveral G, Benet LZ

Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?

Clinical pharmacology and therapeutics

Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA

Benet L Z and Galeazzi R L: noncompartmental determination of the steady-state volume of distribution, J Pharm Sci 68, 1071-1074, 1979--the backstory.

The AAPS journal

Benet LZ

Sotalol permeability in cultured-cell, rat intestine, and PAMPA system.

Pharmaceutical research

Liu W, Okochi H, Benet LZ, Zhai SD

BDDCS class prediction for new molecular entities.

Molecular pharmaceutics

Broccatelli F, Cruciani G, Benet LZ, Oprea TI

Improving the prediction of the brain disposition for orally administered drugs using BDDCS.

Advanced drug delivery reviews

Broccatelli F, Larregieu CA, Cruciani G, Oprea TI, Benet LZ

Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations.

Pharmacotherapy

Frymoyer A, Guglielmo BJ, Wilson SD, Scarpace SB, Benet LZ, Hersh AL

Pharmacokinetic differences corroborate observed low tacrolimus dosage in Native American renal transplant patients.

Drug metabolism and disposition: the biological fate of chemicals

Grover A, Frassetto LA, Benet LZ, Chakkera HA

BDDCS applied to over 900 drugs.

The AAPS journal

Benet LZ, Broccatelli F, Oprea TI

Lead PK commentary: predicting human pharmacokinetics.

Journal of pharmaceutical sciences

Rowland M, Benet LZ

Professor Akira Tsuji: scientist, educator, and leader.

Journal of pharmaceutical sciences

Terasaki T, Sugiyama Y, Benet LZ

Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics.

Journal of pharmaceutical sciences

Reyes M, Benet LZ

Intermittent drug dosing intervals guided by the operational multiple dosing half lives for predictable plasma accumulation and fluctuation.

Journal of pharmacokinetics and pharmacodynamics

Grover A, Benet LZ

The BCS, BDDCS, and regulatory guidances.

Pharmaceutical research

Chen ML, Amidon GL, Benet LZ, Lennernas H, Yu LX

Is Ciprofloxacin a Substrate of P-glycoprotein?

Archives of drug information

Park MS, Okochi H, Benet LZ

Founding figures of pharmacokinetics: tribute to Malcolm Rowland.

Journal of pharmacokinetics and pharmacodynamics

Aarons L, Benet LZ

Clearance (née Rowland) concepts: a downdate and an update.

Journal of pharmacokinetics and pharmacodynamics

Benet LZ

Age and sex differences in the effects of the immunosuppressants cyclosporine, sirolimus and everolimus on rat brain metabolism.

Neurotoxicology

Gottschalk S, Cummins CL, Leibfritz D, Christians U, Benet LZ, Serkova NJ

Effect of single-dose rifampin on the pharmacokinetics of warfarin in healthy volunteers.

Clinical pharmacology and therapeutics

Frymoyer A, Shugarts S, Browne M, Wu AH, Frassetto L, Benet LZ

The FDA should eliminate the ambiguities in the current BCS biowaiver guidance and make public the drugs for which BCS biowaivers have been granted.

Clinical pharmacology and therapeutics

Benet LZ, Larregieu CA

Membrane transporters in drug development.

Nature reviews. Drug discovery

Prediction of vancomycin pharmacodynamics in children with invasive methicillin-resistant Staphylococcus aureus infections: a Monte Carlo simulation.

Clinical therapeutics

Frymoyer A, Hersh AL, Coralic Z, Benet LZ, Joseph Guglielmo B

Hepatic clearance, but not gut availability, of erythromycin is altered in patients with end-stage renal disease.

Clinical pharmacology and therapeutics

Sun H, Frassetto LA, Huang Y, Benet LZ

Stereoselective flunoxaprofen-S-acyl-glutathione thioester formation mediated by acyl-CoA formation in rat hepatocytes.

Drug metabolism and disposition: the biological fate of chemicals

Grillo MP, Wait JC, Tadano Lohr M, Khera S, Benet LZ

Predicting drug disposition via application of a Biopharmaceutics Drug Disposition Classification System.

Basic & clinical pharmacology & toxicology

Benet LZ

Comparison of bidirectional lamivudine and zidovudine transport using MDCK, MDCK-MDR1, and Caco-2 cell monolayers.

Journal of pharmaceutical sciences

de Souza J, Benet LZ, Huang Y, Storpirtis S

The drug transporter-metabolism alliance: uncovering and defining the interplay.

Molecular pharmaceutics

Benet LZ

A Holy Grail of clinical pharmacology: prediction of drug pharmacokinetics and pharmacodynamics in the individual patient.

Clinical pharmacology and therapeutics

Benet LZ

The role of transporters in the pharmacokinetics of orally administered drugs.

Pharmaceutical research

Shugarts S, Benet LZ

Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate.

The Pediatric infectious disease journal

Frymoyer A, Hersh AL, Benet LZ, Guglielmo BJ

Effects of drug transporters on volume of distribution.

The AAPS journal

Grover A, Benet LZ

Nonnucleoside reverse transcriptase inhibitor pharmacokinetics in a large unselected cohort of HIV-infected women.

Journal of acquired immune deficiency syndromes (1999)

Gandhi M, Benet LZ, Bacchetti P, Kalinowski A, Anastos K, Wolfe AR, Young M, Cohen M, Minkoff H, Gange SJ, Greenblatt RM

The operational multiple dosing half-life: a key to defining drug accumulation in patients and to designing extended release dosage forms.

Pharmaceutical research

Sahin S, Benet LZ

Elucidating rifampin's inducing and inhibiting effects on glyburide pharmacokinetics and blood glucose in healthy volunteers: unmasking the differential effects of enzyme induction and transporter inhibition for a drug and its primary metabolite.

Clinical pharmacology and therapeutics

Zheng HX, Huang Y, Frassetto LA, Benet LZ

Moringa oleifera leaf extracts inhibit 6beta-hydroxylation of testosterone by CYP3A4.

Journal of infection in developing countries

Monera TG, Wolfe AR, Maponga CC, Benet LZ, Guglielmo J

Gamma-glutamyltranspeptidase-mediated degradation of diclofenac-S-acyl-glutathione in vitro and in vivo in rat.

Chemical research in toxicology

Grillo MP, Hua F, March KL, Benet LZ, Knutson CG, Ware JA

The use of BDDCS in classifying the permeability of marketed drugs.

Pharmaceutical research

Benet LZ, Amidon GL, Barends DM, Lennernäs H, Polli JE, Shah VP, Stavchansky SA, Yu LX

Differential effects of fibrates on the metabolic activation of 2-phenylpropionic acid in rats.

Drug metabolism and disposition: the biological fate of chemicals

Li C, Grillo MP, Badagnani I, Fife KL, Benet LZ

HIV-infected liver and kidney transplant recipients: 1- and 3-year outcomes.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Roland ME, Barin B, Carlson L, Frassetto LA, Terrault NA, Hirose R, Freise CE, Benet LZ, Ascher NL, Roberts JP, Murphy B, Keller MJ, Olthoff KM, Blumberg EA, Brayman KL, Bartlett ST, Davis CE, McCune JM, Bredt BM, Stablein DM, Stock PG

Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption.

Advanced drug delivery reviews

Custodio JM, Wu CY, Benet LZ

Immunosuppressant pharmacokinetics and dosing modifications in HIV-1 infected liver and kidney transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Frassetto LA, Browne M, Cheng A, Wolfe AR, Roland ME, Stock PG, Carlson L, Benet LZ

Assessment and validation of the MS/MS fragmentation patterns of the macrolide immunosuppressant everolimus.

Journal of mass spectrometry : JMS

Boernsen KO, Egge-Jacobsen W, Inverardi B, Strom T, Streit F, Schiebel HM, Benet LZ, Christians U

Effects of uptake and efflux transporter inhibition on erythromycin breath test results.

Clinical pharmacology and therapeutics

Frassetto LA, Poon S, Tsourounis C, Valera C, Benet LZ

Studies on the metabolism of tolmetin to the chemically reactive acyl-coenzyme A thioester intermediate in rats.

Drug metabolism and disposition: the biological fate of chemicals

Olsen J, Li C, Skonberg C, Bjørnsdottir I, Sidenius U, Benet LZ, Hansen SH

effect of OATP1B transporter inhibition on the pharmacokinetics of atorvastatin in healthy volunteers.

Clinical pharmacology and therapeutics

Lau YY, Huang Y, Frassetto L, Benet LZ

Elucidating the effect of final-day dosing of rifampin in induction studies on hepatic drug disposition and metabolism.

The Journal of pharmacology and experimental therapeutics

Lam JL, Shugarts SB, Okochi H, Benet LZ

In vitro and in vivo correlation of hepatic transporter effects on erythromycin metabolism: characterizing the importance of transporter-enzyme interplay.

Drug metabolism and disposition: the biological fate of chemicals

Lam JL, Okochi H, Huang Y, Benet LZ

Pharmacokinetics of atorvastatin and its hydroxy metabolites in rats and the effects of concomitant rifampicin single doses: relevance of first-pass effect from hepatic uptake transporters, and intestinal and hepatic metabolism.

Drug metabolism and disposition: the biological fate of chemicals

Lau YY, Okochi H, Huang Y, Benet LZ

Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein.

Drug metabolism and disposition: the biological fate of chemicals

Huang Y, Okochi H, May BC, Legname G, Prusiner SB, Benet LZ, Guglielmo BJ, Lin ET

Liquid chromatographic tandem mass spectrometric assay for the uremic toxin 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid in human plasma.

Rapid communications in mass spectrometry : RCM

Huang Y, Sun H, Frassetto L, Benet LZ, Lin ET

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

Antimicrobial agents and chemotherapy

Barr SC, Warner KL, Kornreic BG, Piscitelli J, Wolfe A, Benet L, McKerrow JH

In vitro and in vivo studies on acyl-coenzyme A-dependent bioactivation of zomepirac in rats.

Chemical research in toxicology

Olsen J, Li C, Bjørnsdottir I, Sidenius U, Hansen SH, Benet LZ

Multiple transporters affect the disposition of atorvastatin and its two active hydroxy metabolites: application of in vitro and ex situ systems.

The Journal of pharmacology and experimental therapeutics

Lau YY, Okochi H, Huang Y, Benet LZ

Glucuronidation and the transport of the glucuronide metabolites in LLC-PK1 cells.

Molecular pharmaceutics

Chang JH, Benet LZ

Effects of renal failure on drug transport and metabolism.

Pharmacology & therapeutics

Sun H, Frassetto L, Benet LZ

Effects of short-term alendronate on bone mineral density in haemodialysis patients.

Nephrology (Carlton, Vic.)

Wetmore JB, Benet LZ, Kleinstuck D, Frassetto L

Cyclosporine pharmacokinetics and dosing modifications in human immunodeficiency virus-infected liver and kidney transplant recipients.

Transplantation

Frassetto L, Baluom M, Jacobsen W, Christians U, Roland ME, Stock PG, Carlson L, Benet LZ

Effect of the MDR1 C3435T variant and P-glycoprotein induction on dicloxacillin pharmacokinetics.

Journal of clinical pharmacology

Putnam WS, Woo JM, Huang Y, Benet LZ

There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be found.

Molecular interventions

Benet LZ

Basic pharmacological interactions and how they may impact on one another.

Journal of acquired immune deficiency syndromes (1999)

Benet L

Predicting drug disposition via application of BCS: transport/absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system.

Pharmaceutical research

Wu CY, Benet LZ

Stereoselective taurine conjugation of (R)-benoxaprofen enantiomer in rats: in vivo and in vitro studies using rat hepatic mitochondria and microsomes.

Pharmaceutical research

Mohri K, Okada K, Benet LZ

Hepatic microsome studies are insufficient to characterize in vivo hepatic metabolic clearance and metabolic drug-drug interactions: studies of digoxin metabolism in primary rat hepatocytes versus microsomes.

Drug metabolism and disposition: the biological fate of chemicals

Lam JL, Benet LZ

Automated, fast, and sensitive quantification of drugs in human plasma by LC/LC-MS: quantification of 6 protease inhibitors and 3 nonnucleoside transcriptase inhibitors.

Therapeutic drug monitoring

Egge-Jacobsen W, Unger M, Niemann CU, Baluom M, Hirai S, Benet LZ, Christians U

Novel percutaneous adventitial drug delivery system for regional vascular treatment.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

Ikeno F, Lyons J, Kaneda H, Baluom M, Benet LZ, Rezaee M

Alterations in glucose metabolism by cyclosporine in rat brain slices link to oxidative stress: interactions with mTOR inhibitors.

British journal of pharmacology

Christians U, Gottschalk S, Miljus J, Hainz C, Benet LZ, Leibfritz D, Serkova N

Effects of uremic toxins on hepatic uptake and metabolism of erythromycin.

Drug metabolism and disposition: the biological fate of chemicals

Sun H, Huang Y, Frassetto L, Benet LZ

P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro.

Pharmaceutical research

Kim WY, Benet LZ

Unmasking the dynamic interplay between efflux transporters and metabolic enzymes.

International journal of pharmaceutics

Benet LZ, Cummins CL, Wu CY

Pharmacogenomics and transplantation: where are we?

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Frassetto LA, Benet LZ

Biochemical mechanisms of cyclosporine neurotoxicity.

Molecular interventions

Serkova NJ, Christians U, Benet LZ

Ex situ inhibition of hepatic uptake and efflux significantly changes metabolism: hepatic enzyme-transporter interplay.

The Journal of pharmacology and experimental therapeutics

Lau YY, Wu CY, Okochi H, Benet LZ

Disposition of tacrolimus in isolated perfused rat liver: influence of troleandomycin, cyclosporine, and gg918.

Drug metabolism and disposition: the biological fate of chemicals

Wu CY, Benet LZ

CYP3A4-transfected Caco-2 cells as a tool for understanding biochemical absorption barriers: studies with sirolimus and midazolam.

The Journal of pharmacology and experimental therapeutics

Cummins CL, Jacobsen W, Christians U, Benet LZ

Transporter-enzyme interactions: implications for predicting drug-drug interactions from in vitro data.

Current drug metabolism

Benet LZ, Cummins CL, Wu CY

Covalent binding of 2-phenylpropionyl-S-acyl-CoA thioester to tissue proteins in vitro.

Drug metabolism and disposition: the biological fate of chemicals

Li C, Olurinde MO, Hodges LM, Grillo MP, Benet LZ

In vivo mechanistic studies on the metabolic activation of 2-phenylpropionic acid in rat.

The Journal of pharmacology and experimental therapeutics

Li C, Grillo MP, Benet LZ

In vivo modulation of intestinal CYP3A metabolism by P-glycoprotein: studies using the rat single-pass intestinal perfusion model.

The Journal of pharmacology and experimental therapeutics

Cummins CL, Salphati L, Reid MJ, Benet LZ

In vitro studies on the chemical reactivity of 2,4-dichlorophenoxyacetyl-S-acyl-CoA thioester.

Toxicology and applied pharmacology

Li C, Grillo MP, Benet LZ

Pharmacokinetic interactions between cyclosporine and protease inhibitors in HIV+ subjects.

Drug metabolism and pharmacokinetics

Frassetto L, Thai T, Aggarwal AM, Bucher P, Jacobsen W, Christians U, Benet LZ, Floren LC

Pharmacokinetics of cyclosporine pre- and post-liver transplantation.

Journal of clinical pharmacology

Hebert MF, Wacher VJ, Roberts JP, Benet LZ

Functional characterization of monocarboxylic acid, large neutral amino acid, bile acid and peptide transporters, and P-glycoprotein in MDCK and Caco-2 cells.

Journal of pharmaceutical sciences

Putnam WS, Ramanathan S, Pan L, Takahashi LH, Benet LZ

Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava).

Planta medica

Unger M, Holzgrabe U, Jacobsen W, Cummins C, Benet LZ

Enantioselective covalent binding of 2-phenylpropionic Acid to protein in vitro in rat hepatocytes.

Chemical research in toxicology

Li C, Benet LZ, Grillo MP

Sex-related differences in the clearance of cytochrome P450 3A4 substrates may be caused by P-glycoprotein.

Clinical pharmacology and therapeutics

Cummins CL, Wu CY, Benet LZ

Studies on the chemical reactivity of 2-phenylpropionic acid 1-O-acyl glucuronide and S-acyl-CoA thioester metabolites.

Chemical research in toxicology

Li C, Benet LZ, Grillo MP

Close association between the reduction in myocardial energy metabolism and infarct size: dose-response assessment of cyclosporine.

The Journal of pharmacology and experimental therapeutics

Niemann CU, Saeed M, Akbari H, Jacobsen W, Benet LZ, Christians U, Serkova N

Can the enhanced renal clearance of antibiotics in cystic fibrosis patients be explained by P-glycoprotein transport?

Pharmaceutical research

Susanto M, Benet LZ

Contributions of saturable active secretion, passive transcellular, and paracellular diffusion to the overall transport of furosemide across adenocarcinoma (Caco-2) cells.

Journal of pharmaceutical sciences

Flanagan SD, Takahashi LH, Liu X, Benet LZ

Changes in plasma protein binding have little clinical relevance.

Clinical pharmacology and therapeutics

Benet LZ, Hoener BA

Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Serkova N, Donohoe P, Gottschalk S, Hainz C, Niemann CU, Bickler PE, Litt L, Benet LZ, Leibfritz D, Christians U

Effect of calcineurin inhibitor therapy on P-gp expression and function in lymphocytes of renal transplant patients: a preliminary evaluation.

Journal of clinical pharmacology

Parasrampuria DA, Lantz MV, Birnbaum JL, Vincenti FG, Benet LZ

Unmasking the dynamic interplay between intestinal P-glycoprotein and CYP3A4.

The Journal of pharmacology and experimental therapeutics

Cummins CL, Jacobsen W, Benet LZ

Quantitative liquid chromatography-mass spectrometry determination of isatin in urine using automated on-line extraction.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

Unger M, Jacobsen W, Holzgrabe U, Benet LZ

Comparison of bidirectional cephalexin transport across MDCK and caco-2 cell monolayers: interactions with peptide transporters.

Pharmaceutical research

Putnam WS, Pan L, Tsutsui K, Takahashi L, Benet LZ

Comparison of furosemide and vinblastine secretion from cell lines overexpressing multidrug resistance protein (P-glycoprotein) and multidrug resistance-associated proteins (MRP1 and MRP2).

Pharmacology

Flanagan SD, Cummins CL, Susanto M, Liu X, Takahashi LH, Benet LZ

Mechanisms of clinically relevant drug interactions associated with tacrolimus.

Clinical pharmacokinetics

Christians U, Jacobsen W, Benet LZ, Lampen A

Studies on the reactivity of clofibryl-S-acyl-CoA thioester with glutathione in vitro.

Drug metabolism and disposition: the biological fate of chemicals

Grillo MP, Benet LZ

Red wine decreases cyclosporine bioavailability.

Clinical pharmacology and therapeutics

Tsunoda SM, Harris RZ, Christians U, Velez RL, Freeman RB, Benet LZ, Warshaw A

The drug efflux-metabolism alliance: biochemical aspects.

Advanced drug delivery reviews

Benet LZ, Cummins CL

Effect of alpha-fluorination of valproic acid on valproyl-S-acyl-CoA formation in vivo in rats.

Drug metabolism and disposition: the biological fate of chemicals

Grillo MP, Chiellini G, Tonelli M, Benet LZ

Characterizing the expression of CYP3A4 and efflux transporters (P-gp, MRP1, and MRP2) in CYP3A4-transfected Caco-2 cells after induction with sodium butyrate and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate.

Pharmaceutical research

Cummins CL, Mangravite LM, Benet LZ

Interaction of gamma-glutamyltranspeptidase with clofibryl-S-acyl-glutathione in vitro and in vivo in rat.

Chemical research in toxicology

Grillo MP, Benet LZ

Sirolimus, but not the structurally related RAD (everolimus), enhances the negative effects of cyclosporine on mitochondrial metabolism in the rat brain.

British journal of pharmacology

Serkova N, Jacobsen W, Niemann CU, Litt L, Benet LZ, Leibfritz D, Christians U

Metabolism of sirolimus and its derivative everolimus by cytochrome P450 3A4: insights from docking, molecular dynamics, and quantum chemical calculations.

Journal of medicinal chemistry

Kuhn B, Jacobsen W, Christians U, Benet LZ, Kollman PA

Active secretion and enterocytic drug metabolism barriers to drug absorption.

Advanced drug delivery reviews

Wacher VJ, Salphati L, Benet LZ

Comparison of the in vitro metabolism of the macrolide immunosuppressants sirolimus and RAD.

Transplantation proceedings

Jacobsen W, Serkova N, Hausen B, Morris RE, Benet LZ, Christians U

Membrane transport of mycophenolate mofetil and its active metabolite, mycophenolic acid in MDCK and MDR1-MDCK cell monolayers.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

Sawamoto T, Van Gelder T, Christians U, Okamura N, Jacobsen W, Benet L

A human lymphocyte based ex vivo assay to study the effect of drugs on P-glycoprotein (P-gp) function.

Pharmaceutical research

Parasrampuria DA, Lantz MV, Benet LZ

Identification of hepatic protein targets of the reactive metabolites of the non-hepatotoxic regioisomer of acetaminophen, 3'-hydroxyacetanilide, in the mouse in vivo using two-dimensional gel electrophoresis and mass spectrometry.

Advances in experimental medicine and biology

Qiu Y, Benet LZ, Burlingame AL

The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein.

Clinical pharmacokinetics

Zhang Y, Benet LZ

The pharmacokinetics and metabolic disposition of tacrolimus: a comparison across ethnic groups.

Clinical pharmacology and therapeutics

Mancinelli LM, Frassetto L, Floren LC, Dressler D, Carrier S, Bekersky I, Benet LZ, Christians U

Chiral bioequivalence: effect of absorption rate on racemic etodolac.

Clinical pharmacokinetics

Boni JR, Korth-Bradley JM, Richards LS, Chiang ST, Hicks DR, Benet LZ

In vitro evaluation of the disposition of A novel cysteine protease inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Christians U, Benet LZ

Lactonization is the critical first step in the disposition of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor atorvastatin.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kuhn B, Soldner A, Kirchner G, Sewing KF, Kollman PA, Benet LZ, Christians U

Automated, fast and sensitive quantification of drugs in blood by liquid chromatography-mass spectrometry with on-line extraction: immunosuppressants.

Journal of chromatography. B, Biomedical sciences and applications

Christians U, Jacobsen W, Serkova N, Benet LZ, Vidal C, Sewing KF, Manns MP, Kirchner GI

Tissue distribution and clinical monitoring of the novel macrolide immunosuppressant SDZ-RAD and its metabolites in monkey lung transplant recipients: interaction with cyclosporine.

The Journal of pharmacology and experimental therapeutics

Serkova N, Hausen B, Berry GJ, Jacobsen W, Benet LZ, Morris RE, Christians U

Recommendations for bioequivalence testing of cyclosporine generics revisited.

Therapeutic drug monitoring

Christians U, First MR, Benet LZ

Active transport of the angiotensin-II antagonist losartan and its main metabolite EXP 3174 across MDCK-MDR1 and caco-2 cell monolayers.

British journal of pharmacology

Soldner A, Benet LZ, Mutschler E, Christians U

The novel immunosuppressant SDZ-RAD protects rat brain slices from cyclosporine-induced reduction of high-energy phosphates.

British journal of pharmacology

Serkova N, Litt L, Leibfritz D, Hausen B, Morris RE, James TL, Benet LZ, Christians U

Combined immunosuppression with cyclosporine (neoral) and SDZ RAD in non-human primate lung transplantation: systematic pharmacokinetic-based trials to improve efficacy and tolerability.

Transplantation

Hausen B, Ikonen T, Briffa N, Berry GJ, Christians U, Robbins RC, Hook L, Serkova N, Benet LZ, Schuler W, Morris RE

Ethynylestradiol-mediated induction of hepatic CYP3A9 in female rats: implication for cyclosporine metabolism.

Drug metabolism and disposition: the biological fate of chemicals

Jäger W, Correia MA, Bornheim LM, Mahnke A, Hanstein WG, Xue L, Benet LZ

Intestinal MDR transport proteins and P-450 enzymes as barriers to oral drug delivery.

Journal of controlled release : official journal of the Controlled Release Society

Benet LZ, Izumi T, Zhang Y, Silverman JA, Wacher VJ

Small intestinal metabolism of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor lovastatin and comparison with pravastatin.

The Journal of pharmacology and experimental therapeutics

Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Baner K, Benet LZ, Sewing KF, Christians U

Photoinduced covalent binding of frusemide and frusemide glucuronide to human serum albumin.

British journal of clinical pharmacology

Mizuma T, McDonagh AF, Lin ET, Benet LZ

Evaluation of individual and combined neurotoxicity of the immunosuppressants cyclosporine and sirolimus by in vitro multinuclear NMR spectroscopy.

The Journal of pharmacology and experimental therapeutics

Serkova N, Litt L, James TL, Sadée W, Leibfritz D, Benet LZ, Christians U

Relevance of pharmacokinetics in narrow therapeutic index drugs.

Transplantation proceedings

Benet LZ

Understanding bioequivalence testing.

Transplantation proceedings

Benet LZ

Coadministration of neoral and the novel rapamycin analog, SDZ RAD, to rat lung allograft recipients: potentiation of immunosuppressive efficacy and improvement of tolerability of staggered versus simultaneous treatment.

Transplantation

Hausen B, Boeke K, Berry GJ, Segarra I, Benet LZ, Christians U, Morris RE

Grapefruit juice activates P-glycoprotein-mediated drug transport.

Pharmaceutical research

Soldner A, Christians U, Susanto M, Wacher VJ, Silverman JA, Benet LZ

Interaction of human serum albumin with furosemide glucuronide: a role of albumin in isomerization, hydrolysis, reversible binding and irreversible binding of a 1-O-acyl glucuronide metabolite.

Biopharmaceutics & drug disposition

Mizuma T, Benet LZ, Lin ET

In vitro biotransformation of a novel antimalarial cysteine protease inhibitor in human liver microsomes.

Pharmacology

Zhang Y, Guo X, Lin ET, Benet LZ

Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver.

Drug metabolism and disposition: the biological fate of chemicals

Jacobsen W, Kirchner G, Hallensleben K, Mancinelli L, Deters M, Hackbarth I, Benet LZ, Sewing KF, Christians U

Metabolism of digoxin and digoxigenin digitoxosides in rat liver microsomes: involvement of cytochrome P4503A.

Xenobiotica; the fate of foreign compounds in biological systems

Salphati L, Benet LZ

Molecular and physical mechanisms of first-pass extraction.

Drug metabolism and disposition: the biological fate of chemicals

Hall SD, Thummel KE, Watkins PB, Lown KS, Benet LZ, Paine MF, Mayo RR, Turgeon DK, Bailey DG, Fontana RJ, Wrighton SA

Net secretion of furosemide is subject to indomethacin inhibition, as observed in Caco-2 monolayers and excised rat jejunum.

Pharmaceutical research

Flanagan SD, Benet LZ

Development of a high-performance liquid chromatographic-electrospray mass spectrometric assay for the specific and sensitive quantification of the novel immunosuppressive macrolide 40-O-(2-hydroxyethyl)rapamycin.

Journal of chromatography. B, Biomedical sciences and applications

Segarra I, Brazelton TR, Guterman N, Hausen B, Jacobsen W, Morris RE, Benet LZ, Christians U

Preliminary evaluation of progestins as inducers of cytochrome P450 3A4 activity in postmenopausal women.

Journal of clinical pharmacology

Tsunoda SM, Harris RZ, Mroczkowski PJ, Benet LZ

Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.

Journal of pharmaceutical sciences

Wacher VJ, Silverman JA, Zhang Y, Benet LZ

High-performance liquid chromatographic determination and identification of acyl migration and photodegradation products of furosemide 1-O-acyl glucuronide.

Journal of chromatography. B, Biomedical sciences and applications

Mizuma T, Benet LZ, Lin ET

Characterization of P-glycoprotein mediated transport of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor, across MDR1-MDCK and Caco-2 cell monolayers.

Pharmaceutical research

Zhang Y, Benet LZ

Effects of ketoconazole on the intestinal metabolism, transport and oral bioavailability of K02, a novel vinylsulfone peptidomimetic cysteine protease inhibitor and a P450 3A, P-glycoprotein dual substrate, in male Sprague-Dawley rats.

The Journal of pharmacology and experimental therapeutics

Zhang Y, Hsieh Y, Izumi T, Lin ET, Benet LZ

Impact of intraindividual variability of drugs on therapeutic outcomes: lessons from outside transplantation.

Transplantation proceedings

Benet LZ

Identification of the hepatic protein targets of reactive metabolites of acetaminophen in vivo in mice using two-dimensional gel electrophoresis and mass spectrometry.

The Journal of biological chemistry

Qiu Y, Benet LZ, Burlingame AL

Effects of ketoconazole on digoxin absorption and disposition in rat.

Pharmacology

Salphati L, Benet LZ

Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine.

The Journal of pharmacology and experimental therapeutics

Lampen A, Zhang Y, Hackbarth I, Benet LZ, Sewing KF, Christians U

Overlapping substrate specificities of cytochrome P450 3A and P-glycoprotein for a novel cysteine protease inhibitor.

Drug metabolism and disposition: the biological fate of chemicals

Zhang Y, Guo X, Lin ET, Benet LZ

Stereoselective metabolism of benoxaprofen in rats. Biliary excretion of benoxaprofen taurine conjugate and glucuronide.

Drug metabolism and disposition: the biological fate of chemicals

Mohri K, Okada K, Benet LZ

Antiprogestin-mediated inactivation of cytochrome P450 3A4.

Pharmacology

Jang GR, Benet LZ

Mechanisms for covalent binding of benoxaprofen glucuronide to human serum albumin. Studies By tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals

Qiu Y, Burlingame AL, Benet LZ

Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers.

Biochemical pharmacology

Salphati L, Benet LZ

Preparative chromatography of furosemide 1-O-acyl-glucuronide from urine using micronized amberiite XAD-2 and its application to other 1-O-acyl-glucuronides.

Preparative biochemistry & biotechnology

Mizuma T, Benet LZ, Lin ET

Antiprogestin pharmacodynamics, pharmacokinetics, and metabolism: implications for their long-term use.

Journal of pharmacokinetics and biopharmaceutics

Jang GR, Benet LZ

Cytochrome P4503A4-mediated N-demethylation of the antiprogestins lilopristone and onapristone.

Drug metabolism and disposition: the biological fate of chemicals

Jang GR, Benet LZ

Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine.

Clinical pharmacology and therapeutics

Lown KS, Mayo RR, Leichtman AB, Hsiao HL, Turgeon DK, Schmiedlin-Ren P, Brown MB, Guo W, Rossi SJ, Benet LZ, Watkins PB

Tacrolimus oral bioavailability doubles with coadministration of ketoconazole.

Clinical pharmacology and therapeutics

Floren LC, Bekersky I, Benet LZ, Mekki Q, Dressler D, Lee JW, Roberts JP, Hebert MF

Investigation of aortic CYP3A bioactivation of nitroglycerin in vivo.

The Journal of pharmacology and experimental therapeutics

Yuan R, Sumi M, Benet LZ

Determination of amiprilose in human plasma by high-performance liquid chromatography with fluorimetric detection.

Journal of chromatography. B, Biomedical sciences and applications

Wu ST, Benet LZ, Lin ET

Stereoselective high-performance liquid chromatography determination of propranolol and 4-hydroxypropranolol in human plasma after pre-column derivatization.

Journal of chromatography. B, Biomedical sciences and applications

Wu ST, Chang YP, Gee WL, Benet LZ, Lin ET

Evaluation of orally administered highly variable drugs and drug formulations.

Pharmaceutical research

Shah VP, Yacobi A, Barr WH, Benet LZ, Breimer D, Dobrinska MR, Endrenyi L, Fairweather W, Gillespie W, Gonzalez MA, Hooper J, Jackson A, Lesko LJ, Midha KK, Noonan PK, Patnaik R, Williams RL

Pharmacokinetics and pharmacodynamics of metformin in healthy subjects and patients with noninsulin-dependent diabetes mellitus.

Journal of clinical pharmacology

Sambol NC, Chiang J, O'Conner M, Liu CY, Lin ET, Goodman AM, Benet LZ, Karam JH

Food intake and dosage level, but not tablet vs solution dosage form, affect the absorption of metformin HCl in man.

British journal of clinical pharmacology

Sambol NC, Brookes LG, Chiang J, Goodman AM, Lin ET, Liu CY, Benet LZ

Morality play.

Science (New York, N.Y.)

Benet LZ

Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.

Biochemical pharmacology

Jang GR, Wrighton SA, Benet LZ

In vivo depletion of free thiols does not account for nitroglycerin-induced tolerance: a thiol-nitrate interaction hypothesis as an alternative explanation for nitroglycerin activity and tolerance.

The Journal of pharmacology and experimental therapeutics

Haj-Yehia AI, Benet LZ

Acute dose-dependent disposition studies of nicotinic acid in rats.

Drug metabolism and disposition: the biological fate of chemicals

Iwaki M, Ogiso T, Hayashi H, Tanino T, Benet LZ

Tolerance to nitroglycerin in rabbit aorta. Investigating the involvement of the mu isozyme of glutathione S-transferases.

Biochemical pharmacology

Kenkare SR, Benet LZ

Suppression of intestinal and hepatic cytochrome P4503A in murine Toxoplasma infection. Effects of N-acetylcysteine and N(G)-monomethyl-L-arginine on the hepatic suppression.

Xenobiotica; the fate of foreign compounds in biological systems

Berg-Candolfi M, Candolfi E, Benet LZ

The effects of menopause and hormone replacement therapies on prednisolone and erythromycin pharmacokinetics.

Clinical pharmacology and therapeutics

Harris RZ, Tsunoda SM, Mroczkowski P, Wong H, Benet LZ

Inhibition of cyclosporine and tetrahydrocannabinol metabolism by cannabidiol in mouse and human microsomes.

Xenobiotica; the fate of foreign compounds in biological systems

Jaeger W, Benet LZ, Bornheim LM

The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers.

Clinical pharmacology and therapeutics

Chang T, Benet LZ, Hebert MF

Differentiation of absorption and first-pass gut and hepatic metabolism in humans: studies with cyclosporine.

Clinical pharmacology and therapeutics

Wu CY, Benet LZ, Hebert MF, Gupta SK, Rowland M, Gomez DY, Wacher VJ

Kidney function and age are both predictors of pharmacokinetics of metformin.

Journal of clinical pharmacology

Sambol NC, Chiang J, Lin ET, Goodman AM, Liu CY, Benet LZ, Cogan MG

Synthesis and mass-spectrometric characterization of human serum albumins modified by covalent binding of two non-steroidal anti-inflammatory drugs: tolmetin and zomepirac.

The Biochemical journal

Zia-Amirhosseini P, Ding A, Burlingame AL, McDonagh AF, Benet LZ

Immunopharmacodynamic studies of cyclosporine in patients awaiting renal transplantation.

Journal of clinical pharmacology

d'Uscio CH, Aweeka FT, Prueksaritanont T, Tomlanovich SJ, Gupta SK, Lantz MV, Gambertoglio JG, Garovoy MR, Benet LZ

Stereoselective disposition of naproxen glucuronide in the rat.

Drug metabolism and disposition: the biological fate of chemicals

Iwaki M, Bischer A, Nguyen AC, McDonagh AF, Benet LZ

Stereoselective reversible binding properties of the glucuronide conjugates of fenoprofen enantiomers to human serum albumin.

Drug metabolism and disposition: the biological fate of chemicals

Bischer A, Iwaki M, Zia-Amirhosseini P, Benet LZ

Effect of cannabidiol pretreatment on the kinetics of tetrahydrocannabinol metabolites in mouse brain.

Drug metabolism and disposition: the biological fate of chemicals

Bornheim LM, Kim KY, Li J, Perotti BY, Benet LZ

Gender effects in pharmacokinetics and pharmacodynamics.

Drugs

Harris RZ, Benet LZ, Schwartz JB

Stereoselective binding properties of naproxen glucuronide diastereomers to proteins.

Journal of pharmacokinetics and biopharmaceutics

Bischer A, Zia-Amirhosseini P, Iwaki M, McDonagh AF, Benet LZ

Bioequivalence and narrow therapeutic index drugs.

Pharmacotherapy

Benet LZ, Goyan JE

Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.

Molecular carcinogenesis

Wacher VJ, Wu CY, Benet LZ

The effects of ketoconazole on the intestinal metabolism and bioavailability of cyclosporine.

Clinical pharmacology and therapeutics

Gomez DY, Wacher VJ, Tomlanovich SJ, Hebert MF, Benet LZ

Time course of cyclosporine and ist motabolites in blood, liver and spleen of naive Lewis rats: comparison with preliminary data obtained in transplanted animals.

Biopharmaceutics & drug disposition

Wacher VJ, Liu T, Roberts JP, Ascher NL, Benet LZ

2-(4-N-maleimidophenyl)-6-methoxybenzofuran: a superior derivatizing agent for fluorimetric determination of aliphatic thiols by high-performance liquid chromatography.

Journal of chromatography. B, Biomedical applications

Haj-Yehia AI, Benet LZ

Dissociation of tissue thiols content from nitroglycerin-induced cyclic-3',5'-guanosine monophosphate and the state of tolerance: in vivo experiments in rats.

The Journal of pharmacology and experimental therapeutics

Haj-Yehia AI, Benet LZ

Basic principles of pharmacokinetics.

Toxicologic pathology

Benet LZ, Zia-Amirhosseini P

Biliary excretion of furosemide glucuronide in rabbits.

Biological & pharmaceutical bulletin

Sekikawa H, Yagi N, Oda K, Kenmotsu H, Takada M, Chen HF, Lin ET, Benet LZ

Reactivity of tolmetin glucuronide with human serum albumin. Identification of binding sites and mechanisms of reaction by tandem mass spectrometry.

Drug metabolism and disposition: the biological fate of chemicals

Ding A, Zia-Amirhosseini P, McDonagh AF, Burlingame AL, Benet LZ

Apparent intramolecular acyl migration and hydrolysis of furosemide glucuronide in aqueous solution.

Biological & pharmaceutical bulletin

Sekikawa H, Yagi N, Lin ET, Benet LZ

Determination of aliphatic thiols by fluorometric high-performance liquid chromatography after precolumn derivatization with 2-(4-N-maleimidophenyl)-6-methylbenzothiazole.

Pharmaceutical research

Haj-Yehia AI, Benet LZ

Hypersensitivity to nonsteroidal anti-inflammatory drugs.

Nature medicine

Zia-Amirhosseini PZ, Harris RZ, Brodsky FM, Benet LZ

Correlation of the response to nitroglycerin in rabbit aorta with the activity of the mu class glutathione S-transferase.

Biochemical pharmacology

Kenkare SR, Han C, Benet LZ

Simultaneous measurement of nicotinic acid and its major metabolite, nicotinuric acid in urine using high-performance liquid chromatography: application of solid-liquid extraction.

Journal of chromatography. B, Biomedical applications

Iwaki M, Ogiso T, Hayashi H, Lin ET, Benet LZ

HPLC assay for FK 506 and two metabolites in isolated rat hepatocytes and rat liver microsomes.

Pharmaceutical research

Perotti BY, Prueksaritanont T, Benet LZ

Irreversible binding of tolmetin to macromolecules via its glucuronide: binding to blood constituents, tissue homogenates and subcellular fractions in vitro.

Xenobiotica; the fate of foreign compounds in biological systems

Ojingwa JC, Spahn-Langguth H, Benet LZ

Menopause: pharmacodynamics and pharmacokinetics.

Experimental gerontology

Gustavson LE, Benet LZ

Pharmacokinetics of nitroglycerin and its four metabolites during nitroglycerin transdermal administration.

Biopharmaceutics & drug disposition

Han C, Jung P, Sanders SW, Lin ET, Benet LZ

Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development.

Journal of clinical pharmacology

Peck CC, Barr WH, Benet LZ, Collins J, Desjardins RE, Furst DE, Harter JG, Levy G, Ludden T, Rodman JH

Reversible binding of tolmetin, zomepirac, and their glucuronide conjugates to human serum albumin and plasma.

Journal of pharmacokinetics and biopharmaceutics

Ojingwa JC, Spahn-Langguth H, Benet LZ

Bioactivation by glucuronide-conjugate formation.

Advances in pharmacology (San Diego, Calif.)

Zia-Amirhosseini P, Spahn-Langguth H, Benet LZ

Enhanced covalent binding of tolmetin to proteins in humans after multiple dosing.

Clinical pharmacology and therapeutics

Zia-Amirhosseini P, Ojingwa JC, Spahn-Langguth H, McDonagh AF, Benet LZ

FK 506 metabolism in male and female rat liver microsomes.

Drug metabolism and disposition: the biological fate of chemicals

Perotti BY, Okudaira N, Prueksaritanont T, Benet LZ

Pharmacokinetic profile of etodolac in special populations.

European journal of rheumatology and inflammation

Benet LZ

Pharmacokinetics of orally and intravenously administered cyclosporine in pre-kidney transplant patients.

Journal of clinical pharmacology

Aweeka FT, Tomlanovich SJ, Prueksaritanont T, Gupta SK, Benet LZ

Pharmacokinetics--a relevant factor for the choice of a drug?

Alimentary pharmacology & therapeutics

Benet LZ, Zech K

Pharmacokinetics and irreversible binding of tolmetin and its glucuronic acid esters in the elderly.

Pharmacology

Munafo A, Hyneck ML, Benet LZ

Pharmacokinetics and pharmacodynamics of nitroglycerin and its dinitrate metabolites in conscious dogs: intravenous infusion studies.

Journal of pharmacokinetics and biopharmaceutics

Lee FW, Salmonson T, Benet LZ

Simultaneous pharmacodynamic modeling of the non-steady-state effects of three oral doses of 1,3-glyceryl dinitrate upon blood pressure in healthy volunteers.

Journal of pharmacokinetics and biopharmaceutics

Gumbleton M, Benet LZ

Effect of ethacrynic acid, a glutathione-S-transferase inhibitor, on nitroglycerin-mediated cGMP elevation and vasorelaxation of rabbit aortic strips.

Biochemical pharmacology

Kenkare SR, Benet LZ

Cyclosporine metabolism by rat liver microsomes. Evidence for involvement of enzyme(s) other than cytochromes P-450 3A.

Drug metabolism and disposition: the biological fate of chemicals

Prueksaritanont T, Correia MA, Rettie AE, Swinney DC, Thomas PE, Benet LZ

Interpretation and utilization of effect and concentration data collected in an in vivo pharmacokinetic and in vitro pharmacodynamic study.

Pharmaceutical research

Gupta SK, Hwang SS, Benet LZ, Gumbleton M

Evidence for covalent binding of acyl glucuronides to serum albumin via an imine mechanism as revealed by tandem mass spectrometry.

Proceedings of the National Academy of Sciences of the United States of America

Ding A, Ojingwa JC, McDonagh AF, Burlingame AL, Benet LZ

Microsomal acyl glucuronidation: enzyme-kinetic studies with labile glucuronides.

Pharmacology

Spahn-Langguth H, Benet LZ

Nitroglycerin dinitrate metabolites do not affect the pharmacokinetics and pharmacodynamics of nitroglycerin in the dog: a preliminary report.

Journal of pharmacokinetics and biopharmaceutics

Lee FW, Hu J, Metzler CH, Benet LZ

New techniques in drug metabolism and clinical pharmacology/pharmacokinetics.

American biotechnology laboratory

Benet LZ

In vitro and in vivo irreversible plasma protein binding of beclobric acid enantiomers.

Chirality

Mayer S, Mutschler E, Benet LZ, Sphahn-Langguth H

Pharmacokinetics of sustained-release etodolac.

Rheumatology international

Benet LZ

Predictability of the covalent binding of acidic drugs in man.

Life sciences

Benet LZ, Spahn-Langguth H, Iwakawa S, Volland C, Mizuma T, Mayer S, Mutschler E, Lin ET

Comparison of vasodilatory responses to nitroglycerin and its dinitrate metabolites in human veins.

Clinical pharmacology and therapeutics

Haefeli WE, Gumbleton M, Benet LZ, Hoffman BB, Blaschke TF

Bioavailability of cyclosporine with concomitant rifampin administration is markedly less than predicted by hepatic enzyme induction.

Clinical pharmacology and therapeutics

Hebert MF, Roberts JP, Prueksaritanont T, Benet LZ

Glutathione S-transferase-mediated metabolism of glyceryl trinitrate in subcellular fractions of bovine coronary arteries.

Pharmaceutical research

Lau DT, Chan EK, Benet LZ

Elderly, conscious patients have an accentuated hypotensive response to nitroglycerin.

Anesthesiology

Cahalan MK, Hashimoto Y, Aizawa K, Verotta D, Ionescu P, Balea M, Eger EI, Benet LZ, Ehrenfeld WK, Goldstone J

Improved gas chromatographic assay for the simultaneous determination of nitroglycerin and its mono- and dinitrate metabolites.

Journal of chromatography

Han C, Gumbleton M, Lau DT, Benet LZ

The interconversion of prednisone and prednisolone in human and rabbit organs in vitro is a function of tissue integrity.

Pharmacology

Hale VG, Benet LZ

Pharmacological activity of the dinitrate metabolites of nitroglycerin following their oral administration to healthy volunteers.

British journal of clinical pharmacology

Gumbleton M, Benet LZ

Report of the workshop on in vitro and in vivo testing and correlation for oral controlled/modified-release dosage forms.

Journal of pharmaceutical sciences

Skelley JP, Amidon GL, Barr WH, Benet LZ, Carter JE, Robinson JR, Shah VP, Yacobi A

Determination of soluble IL-2 receptors in kidney graft recipients--a 6-month follow-up.

Transplantation proceedings

Manfro RC, Pohanka E, Tomlanovich SJ, Benet LZ, Salvatierra O, Garovoy MR

Effect of food on the pharmacokinetics of cyclosporine in healthy subjects following oral and intravenous administration.

Journal of clinical pharmacology

Gupta SK, Manfro RC, Tomlanovich SJ, Gambertoglio JG, Garovoy MR, Benet LZ

Nitroglycerin metabolism in subcellular fractions of rabbit liver. Dose dependency of glyceryl dinitrate formation and possible involvement of multiple isozymes of glutathione S-transferases.

Drug metabolism and disposition: the biological fate of chemicals

Lau DT, Benet LZ

Comparative study of acetaminophen disposition in sheep at three developmental stages: the fetal, neonatal and adult periods.

Developmental pharmacology and therapeutics

Wang LH, Rudolph AM, Benet LZ

Effect of esterase inhibition on the disposition of zomepirac glucuronide and its covalent binding to plasma proteins in the guinea pig.

The Journal of pharmacology and experimental therapeutics

Smith PC, McDonagh AF, Benet LZ

An integrated approach to pharmacokinetic analysis for linear mammillary systems in which input and exit may occur in/from any compartment.

Journal of pharmacokinetics and biopharmaceutics

Nakashima E, Benet LZ

Pharmacokinetics of nicotinic acid-salicylic acid interaction.

Clinical pharmacology and therapeutics

Ding RW, Kolbe K, Merz B, de Vries J, Weber E, Benet LZ

Absorption kinetics of cyclosporine in healthy volunteers.

Biopharmaceutics & drug disposition

Gupta SK, Benet LZ

Determination of mean input time, mean residence time, and steady-state volume of distribution with multiple drug inputs.

Journal of pharmacokinetics and biopharmaceutics

Watari N, Benet LZ

Simultaneous measurement of prednisone, prednisolone and 6 beta-hydroxyprednisolone in urine by high-performance liquid chromatography using dexamethasone as the internal standard.

Journal of chromatography

Teng RL, Benet LZ

Application of clearance concepts to the assessment of exposure to lead in drinking water.

American journal of public health

Bois FY, Tozer TN, Zeise L, Benet LZ

Direct determination of diastereomeric carprofen glucuronides in human plasma and urine and preliminary measurements of stereoselective metabolic and renal elimination after oral administration of carprofen in man.

Drug metabolism and disposition: the biological fate of chemicals

Iwakawa S, Suganuma T, Lee SF, Spahn H, Benet LZ, Lin ET

Lead exposure in children vs adults.

American journal of public health

Bois FY, Tozer TN, Benet LZ, Zeise L

Prediction of the distribution volumes of cefazolin and tobramycin in obese children based on physiological pharmacokinetic concepts.

Pharmaceutical research

Koshida R, Nakashima E, Taniguchi N, Tsuji A, Benet LZ, Ichimura F

Procedures to characterize in vivo and in vitro enantioselective glucuronidation properly: studies with benoxaprofen glucuronides.

Pharmaceutical research

Spahn H, Iwakawa S, Lin ET, Benet LZ

Measurement of carprofen enantiomer concentrations in plasma and urine using L-leucinamide as the chiral coupling component.

Journal of chromatography

Spahn H, Spahn I, Pflugmann G, Mutschler E, Benet LZ

Pharmacokinetics of nitroglycerin and metabolites in humans following oral dosing.

Biopharmaceutics & drug disposition

Yu DK, Williams RL, Benet LZ, Lin ET, Giesing DH

General treatment of mean residence time, clearance, and volume parameters in linear mammillary models with elimination from any compartment.

Journal of pharmacokinetics and biopharmaceutics

Nakashima E, Benet LZ

Ion-paired liquid chromatographic method for the analysis of blood and plasma for the antimalarial drug halofantrine and its putative mono-debutylated metabolite.

Journal of chromatography

Gawienowski M, Benet LZ, Fleckenstein L, Lin ET

Disposition and irreversible plasma protein binding of tolmetin in humans.

Clinical pharmacology and therapeutics

Hyneck ML, Smith PC, Munafo A, McDonagh AF, Benet LZ

Effect of cimetidine or ranitidine administration on nifedipine pharmacokinetics and pharmacodynamics.

Clinical pharmacology and therapeutics

Schwartz JB, Upton RA, Lin ET, Williams RL, Benet LZ

Simultaneous determination of nitroglycerin and its dinitrate metabolites by capillary gas chromatography with electron-capture detection.

Journal of chromatography

Lee FW, Watari N, Rigod J, Benet LZ

Effect of pH on acyl migration and hydrolysis of tolmetin glucuronide.

Drug metabolism and disposition: the biological fate of chemicals

Hyneck ML, Munafo A, Benet LZ

Organic anion transport by basal-lateral membranes: effect of PAH and furosemide on each other's transport.

Pharmacology

Gloff CA, Mamelok RD, Benet LZ

High-performance liquid chromatographic determination of tolmetin, tolmetin glucuronide and its isomeric conjugates in plasma and urine.

Journal of chromatography

Hyneck ML, Smith PC, Unseld E, Benet LZ

Variable glyceryl dinitrate formation as a function of route of nitroglycerin administration.

Clinical pharmacology and therapeutics

Noonan PK, Benet LZ

Effects of formulation and food on the absorption of hydrochlorothiazide and triamterene or amiloride from combination diuretic products.

Pharmaceutical research

Williams RL, Mordenti J, Upton RA, Lin ET, Gee WL, Blume CD, Benet LZ

Transdermal bioavailability and first-pass skin metabolism: a preliminary evaluation with nitroglycerin.

Journal of pharmacokinetics and biopharmaceutics

Nakashima E, Noonan PK, Benet LZ

Pharmacokinetics and excretion of unique beta-adrenergic agonists.

Pharmacology

Ferraiolo BL, Halldin MM, Asscher Y, Akita Y, Melmon KL, Benet LZ, Castagnoli N

Developmental alterations in hepatic UDP-glucuronosyltransferase. A comparison of the kinetic properties of enzymes from adult sheep and fetal lambs.

Biochemical pharmacology

Wang LH, Zakim D, Rudolph AM, Benet LZ

AAPS and pharmaceutical research.

Pharmaceutical research

Benet LZ

Absorption and disposition of two combination formulations of hydrochlorothiazide and triamterene: influence of age and renal function.

Clinical pharmacology and therapeutics

Williams RL, Thornhill MD, Upton RA, Blume C, Clark TS, Lin E, Benet LZ

High-performance liquid chromatographic assay of basic amine drugs in plasma and urine using a silica gel column and an aqueous mobile phase. I. Amiloride.

Journal of chromatography

Shi RJ, Benet LZ, Lin ET

The macromolecular binding of prednisone in plasma of healthy volunteers including pregnant women and oral contraceptive users.

Journal of pharmacokinetics and biopharmaceutics

Gustavson LE, Benet LZ

Immunosuppressive activity of prednisone and prednisolone and their metabolic interconversion in the mixed lymphocyte reaction.

International journal of immunopharmacology

Tsang SY, Garovoy MR, Benet LZ

Determination of picogram nitroglycerin plasma concentrations using capillary gas chromatography with on-column injection.

Journal of pharmaceutical sciences

Noonan PK, Kanfer I, Riegelman S, Benet LZ

Liquid chromatographic analysis of triamterene and its major metabolite, hydroxytriamterene sulfate, in blood, plasma, and urine.

Journal of pharmaceutical sciences

Sörgel F, Lin ET, Hasegawa J, Benet LZ

Simultaneous determination of zomepirac and its major metabolite zomepirac glucuronide in human plasma and urine.

Journal of chromatography

Langendijk PN, Smith PC, Hasegawa J, Benet LZ

High-performance liquid chromatographic method for the determination of indomethacin and its two primary metabolites in urine.

Journal of chromatography

Smith PC, Benet LZ

Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases.

Journal of dental research

Lozada F, Frey FJ, Benet LZ

Endogenous hydrocortisone, a possible factor contributing to the genesis of cushingoid habitus in patients on prednisone.

The Journal of clinical endocrinology and metabolism

Frey FJ, Amend WJ, Lozada F, Frey BM, Benet LZ

Membrane populations of bovine choroid plexus: separation by density gradient centrifugation in modified colloidal silica.

Journal of neurochemistry

Mamelok RD, Macrae DR, Benet LZ, Prusiner SB

Induction kinetics of human suppressor cells in the mixed lymphocyte reaction and influence of prednisolone on their genesis.

Cellular immunology

Frey BM, Frey FJ, Cochrum KC, Benet LZ

General method for determining macrodissociation constants of polyprotic, amphoteric compounds from solubility measurements.

Journal of pharmaceutical sciences

Peck CC, Benet LZ

Inappropriate use of the law of corresponding areas to calculate the time course of absorption for multicompartmental systems.

Journal of pharmacokinetics and biopharmaceutics

Galeazzi RL, Benet LZ

Limitations in interpretation of digoxin adsorption using averaged pharmacological response intensities.

Journal of pharmaceutical sciences

Gustafson JH, Schoenwald RD, Benet LZ

The renal elimination of procainamide.

Clinical pharmacology and therapeutics

Galeazzi RL, Sheiner LB, Lockwood T, Benet LZ

Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references.

Journal of pharmacokinetics and biopharmaceutics

Pagliaro LA, Benet LZ

Effect of inert tablet ingredients on drug absorption. I. Effect of polyethylene glycol 4000 on the intestinal absorption of four barbiturates.

Journal of pharmaceutical sciences

Singh P, Guillory JK, Sokoloski TD, Benet LZ, Bhatia VN

Nonlogarithmic titration curves for the determination of dissociation constants and purity.

Journal of pharmaceutical sciences

Benet LZ, Goyan JE

Determination of the stability constants of tetracycline complexes.

Journal of pharmaceutical sciences

Benet LZ, Goyan JE

Publications